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Hepatocyte Growth Factor Reduces Free Cholesterol-Mediated Lipotoxicity in Primary Hepatocytes by Countering Oxidative Stress
Joint Authors
Clavijo-Cornejo, Denise
Uribe-Carvajal, Salvador
Domínguez-Pérez, Mayra
Nuño-Lámbarri, Natalia
Luna-López, Armando
Souza, Verónica
Bucio, Leticia
Miranda, Roxana U.
Muñoz, Linda
Gomez-Quiroz, Luis Enrique
Gutiérrez-Ruiz, María Concepción
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cholesterol overload in the liver has shown toxic effects by inducing the aggravation of nonalcoholic fatty liver disease to steatohepatitis and sensitizing to damage.
Although the mechanism of damage is complex, it has been demonstrated that oxidative stress plays a prominent role in the process.
In addition, we have proved that hepatocyte growth factor induces an antioxidant response in hepatic cells; in the present work we aimed to figure out the protective effect of this growth factor in hepatocytes overloaded with free cholesterol.
Hepatocytes from mice fed with a high-cholesterol diet were treated or not with HGF, reactive oxygen species present in cholesterol overloaded hepatocytes significantly decreased, and this effect was particularly associated with the increase in glutathione and related enzymes, such as γ-gamma glutamyl cysteine synthetase, GSH peroxidase, and GSH-S-transferase.
Our data clearly indicate that HGF displays an antioxidant response by inducing the glutathione-related protection system.
American Psychological Association (APA)
Domínguez-Pérez, Mayra& Nuño-Lámbarri, Natalia& Clavijo-Cornejo, Denise& Luna-López, Armando& Souza, Verónica& Bucio, Leticia…[et al.]. 2016. Hepatocyte Growth Factor Reduces Free Cholesterol-Mediated Lipotoxicity in Primary Hepatocytes by Countering Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114268
Modern Language Association (MLA)
Domínguez-Pérez, Mayra…[et al.]. Hepatocyte Growth Factor Reduces Free Cholesterol-Mediated Lipotoxicity in Primary Hepatocytes by Countering Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1114268
American Medical Association (AMA)
Domínguez-Pérez, Mayra& Nuño-Lámbarri, Natalia& Clavijo-Cornejo, Denise& Luna-López, Armando& Souza, Verónica& Bucio, Leticia…[et al.]. Hepatocyte Growth Factor Reduces Free Cholesterol-Mediated Lipotoxicity in Primary Hepatocytes by Countering Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114268
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114268