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Hydrogen Sulfide Improves Endothelial Dysfunction via Downregulating BMP4COX-2 Pathway in Rats with Hypertension
Joint Authors
Jin, Sheng
Xiao, Lin
Dong, Jing-Hui
Xue, Hong-Mei
Guo, Qi
Teng, Xu
Wu, Yu-Ming
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aims.
We object to elucidate that protective effect of H2S on endothelium is mediated by downregulating BMP4 (bone morphogenetic protein 4)/cyclooxygenase- (COX-) 2 pathway in rats with hypertension.
Methods and Results.
The hypertensive rat model induced by two-kidney one-clip (2K1C) model was used.
Exogenous NaHS administration (56 μmol/kg/day, intraperitoneally once a day) reduced mean arterial pressure (MAP) of 2K1C rats from 199.9 ± 3.312 mmHg to 159.4 ± 5.434 mmHg, while NaHS did not affect the blood pressure in the Sham rats and ameliorated endothelium-dependent contractions (EDCs) of renal artery in 2K1C rats.
2K1C reduced CSE level twofold, decreased plasma levels of H2S about 6-fold, increased BMP4, Nox2, and Nox4 levels 2-fold and increased markers of oxidative stress MDA and nitrotyrosine 1.5-fold, upregulated the expression of phosphorylation-p38 MAPK 2-fold, and increased protein levels of COX-2 1.5-fold, which were abolished by NaHS treatment.
Conclusions.
Our results demonstrate that H2S prevents activation of BMP4/COX-2 pathway in hypertension, which may be involved in the ameliorative effect of H2S on endothelial impairment.
These results throw light on endothelial protective effect of H2S and provide new target for prevention and therapy of hypertension.
American Psychological Association (APA)
Xiao, Lin& Dong, Jing-Hui& Jin, Sheng& Xue, Hong-Mei& Guo, Qi& Teng, Xu…[et al.]. 2016. Hydrogen Sulfide Improves Endothelial Dysfunction via Downregulating BMP4COX-2 Pathway in Rats with Hypertension. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114287
Modern Language Association (MLA)
Xiao, Lin…[et al.]. Hydrogen Sulfide Improves Endothelial Dysfunction via Downregulating BMP4COX-2 Pathway in Rats with Hypertension. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1114287
American Medical Association (AMA)
Xiao, Lin& Dong, Jing-Hui& Jin, Sheng& Xue, Hong-Mei& Guo, Qi& Teng, Xu…[et al.]. Hydrogen Sulfide Improves Endothelial Dysfunction via Downregulating BMP4COX-2 Pathway in Rats with Hypertension. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114287
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114287