Potential Therapeutic Strategies for Hypertension-Exacerbated Cardiotoxicity of Anticancer Drugs
Joint Authors
Xi, L.
Kuriakose, Robin K.
Kukreja, Rakesh C.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Despite their recognized cardiotoxic effects, anthracyclines remain an essential component in many anticancer regimens due to their superior antitumor efficacy.
Epidemiologic data revealed that about one-third of cancer patients have hypertension, which is the most common comorbidity in cancer registries.
The purpose of this review is to assess whether anthracycline chemotherapy exacerbates cardiotoxicity in patients with hypertension.
A link between hypertension comorbidity and anthracycline-induced cardiotoxicity (AIC) was first suggested in 1979.
Subsequent preclinical and clinical studies have supported the notion that hypertension is a major risk factor for AIC, along with the cumulative anthracycline dosage.
There are several common or overlapping pathological mechanisms in AIC and hypertension, such as oxidative stress.
Current evidence supports the utility of cardioprotective modalities as adjunct treatment prior to and during anthracycline chemotherapy.
Several promising cardioprotective approaches against AIC pathologies include dexrazoxane, early hypertension management, and dietary supplementation of nitrate with beetroot juice or other medicinal botanical derivatives (e.g., visnagin and Danshen), which have both antihypertensive and anti-AIC properties.
Future research is warranted to further elucidate the mechanisms of hypertension and AIC comorbidity and to conduct well-controlled clinical trials for identifying effective clinical strategies to improve long-term prognoses in this subgroup of cancer patients.
American Psychological Association (APA)
Kuriakose, Robin K.& Kukreja, Rakesh C.& Xi, L.. 2016. Potential Therapeutic Strategies for Hypertension-Exacerbated Cardiotoxicity of Anticancer Drugs. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114289
Modern Language Association (MLA)
Kuriakose, Robin K.…[et al.]. Potential Therapeutic Strategies for Hypertension-Exacerbated Cardiotoxicity of Anticancer Drugs. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114289
American Medical Association (AMA)
Kuriakose, Robin K.& Kukreja, Rakesh C.& Xi, L.. Potential Therapeutic Strategies for Hypertension-Exacerbated Cardiotoxicity of Anticancer Drugs. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114289
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114289