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Açai (Euterpe oleracea Mart.) Upregulates Paraoxonase 1 Gene Expression and Activity with Concomitant Reduction of Hepatic Steatosis in High-Fat Diet-Fed Rats
Joint Authors
Silva, Marcelo Eustáquio
Pedrosa, Maria Lucia
Lima, Wanderson Geraldo
Silva, Maísa
Guerra, Joyce Ferreira da Costa
Pereira, Renata Rebeca
Abreu, Isabel Cristina Mallosto Emerich de
Lage, Nara Nunes
Lopes, Juliana Márcia Macedo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Açai (Euterpe oleracea Mart.), a fruit from the Amazon region, has emerged as a promising source of polyphenols.
Açai consumption has been increasing owing to ascribed health benefits and antioxidant properties; however, its effects on hepatic injury are limited.
In this study, we evaluated the antioxidant effect of filtered açai pulp on the expression of paraoxonase (PON) isoforms and PON1 activity in rats with nonalcoholic fatty liver disease (NAFLD).
The rats were fed a standard AIN-93M (control) diet or a high-fat (HF) diet containing 25% soy oil and 1% cholesterol with or without açai pulp (2 g/day) for 6 weeks.
Our results show that açai pulp prevented low-density lipoprotein (LDL) oxidation, increased serum and hepatic PON1 activity, and upregulated the expression of PON1 and ApoA-I in the liver.
In HF diet-fed rats, treatment with açai pulp attenuated liver damage, reducing fat infiltration and triglyceride (TG) content.
In rats receiving açai, increased serum PON1 activity was correlated with a reduction in hepatic steatosis and hepatic injury.
These findings suggest the use of açai as a potential therapy for liver injuries, supporting the idea that dietary antioxidants are a promising approach to enhance the defensive systems against oxidative stress.
American Psychological Association (APA)
Pereira, Renata Rebeca& Abreu, Isabel Cristina Mallosto Emerich de& Guerra, Joyce Ferreira da Costa& Lage, Nara Nunes& Lopes, Juliana Márcia Macedo& Silva, Maísa…[et al.]. 2016. Açai (Euterpe oleracea Mart.) Upregulates Paraoxonase 1 Gene Expression and Activity with Concomitant Reduction of Hepatic Steatosis in High-Fat Diet-Fed Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114352
Modern Language Association (MLA)
Pereira, Renata Rebeca…[et al.]. Açai (Euterpe oleracea Mart.) Upregulates Paraoxonase 1 Gene Expression and Activity with Concomitant Reduction of Hepatic Steatosis in High-Fat Diet-Fed Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1114352
American Medical Association (AMA)
Pereira, Renata Rebeca& Abreu, Isabel Cristina Mallosto Emerich de& Guerra, Joyce Ferreira da Costa& Lage, Nara Nunes& Lopes, Juliana Márcia Macedo& Silva, Maísa…[et al.]. Açai (Euterpe oleracea Mart.) Upregulates Paraoxonase 1 Gene Expression and Activity with Concomitant Reduction of Hepatic Steatosis in High-Fat Diet-Fed Rats. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114352
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114352