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Chlorinated Phospholipids and Fatty Acids: (Patho)physiological Relevance, Potential Toxicity, and Analysis of Lipid Chlorohydrins
Joint Authors
Schiller, Jürgen
Schröter, Jenny
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-26, 26 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-20
Country of Publication
Egypt
No. of Pages
26
Main Subjects
Abstract EN
Chlorinated phospholipids are formed by the reaction of hypochlorous acid (HOCl), generated by the enzyme myeloperoxidase under inflammatory conditions, and the unsaturated fatty acyl residues or the head group.
In the first case the generated chlorohydrins are both proinflammatory and cytotoxic, thus having a significant impact on the structures of biomembranes.
The latter case leads to chloramines, the properties of which are by far less well understood.
Since HOCl is also widely used as a disinfecting and antibacterial agent in medicinal, industrial, and domestic applications, it may represent an additional source of danger in the case of abuse or mishandling.
This review discusses the reaction behavior of in vivo generated HOCl and biomolecules like DNA, proteins, and carbohydrates but will focus on phospholipids.
Not only the beneficial and pathological (toxic) effects of chlorinated lipids but also the importance of these chlorinated species is discussed.
Some selected cleavage products of (chlorinated) phospholipids and plasmalogens such as lysophospholipids, (chlorinated) free fatty acids and α-chloro fatty aldehydes, which are all well known to massively contribute to inflammatory diseases associated with oxidative stress, will be also discussed.
Finally, common analytical methods to study these compounds will be reviewed with focus on mass spectrometric techniques.
American Psychological Association (APA)
Schröter, Jenny& Schiller, Jürgen. 2016. Chlorinated Phospholipids and Fatty Acids: (Patho)physiological Relevance, Potential Toxicity, and Analysis of Lipid Chlorohydrins. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-26.
https://search.emarefa.net/detail/BIM-1114356
Modern Language Association (MLA)
Schröter, Jenny& Schiller, Jürgen. Chlorinated Phospholipids and Fatty Acids: (Patho)physiological Relevance, Potential Toxicity, and Analysis of Lipid Chlorohydrins. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-26.
https://search.emarefa.net/detail/BIM-1114356
American Medical Association (AMA)
Schröter, Jenny& Schiller, Jürgen. Chlorinated Phospholipids and Fatty Acids: (Patho)physiological Relevance, Potential Toxicity, and Analysis of Lipid Chlorohydrins. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-26.
https://search.emarefa.net/detail/BIM-1114356
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114356