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Cardiovascular and Hepatic Toxicity of Cocaine: Potential Beneficial Effects of Modulators of Oxidative Stress
Joint Authors
Grassi, Maria Caterina
Graziani, Manuela
Antonilli, Letizia
Togna, Anna Rita
Badiani, Aldo
Saso, Luciano
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-28
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Oxidative stress (OS) is thought to play an important role in the pharmacological and toxic effects of various drugs of abuse.
Herein we review the literature on the mechanisms responsible for the cardiovascular and hepatic toxicity of cocaine with special focus on OS-related mechanisms.
We also review the preclinical and clinical literature concerning the putative therapeutic effects of OS modulators (such as N-acetylcysteine, superoxide dismutase mimetics, nitroxides and nitrones, NADPH oxidase inhibitors, xanthine oxidase inhibitors, and mitochondriotropic antioxidants) for the treatment of cocaine toxicity.
We conclude that available OS modulators do not appear to have clinical efficacy.
American Psychological Association (APA)
Graziani, Manuela& Antonilli, Letizia& Togna, Anna Rita& Grassi, Maria Caterina& Badiani, Aldo& Saso, Luciano. 2015. Cardiovascular and Hepatic Toxicity of Cocaine: Potential Beneficial Effects of Modulators of Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1114363
Modern Language Association (MLA)
Graziani, Manuela…[et al.]. Cardiovascular and Hepatic Toxicity of Cocaine: Potential Beneficial Effects of Modulators of Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1114363
American Medical Association (AMA)
Graziani, Manuela& Antonilli, Letizia& Togna, Anna Rita& Grassi, Maria Caterina& Badiani, Aldo& Saso, Luciano. Cardiovascular and Hepatic Toxicity of Cocaine: Potential Beneficial Effects of Modulators of Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1114363
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114363