Cardiovascular and Hepatic Toxicity of Cocaine: Potential Beneficial Effects of Modulators of Oxidative Stress

Joint Authors

Grassi, Maria Caterina
Graziani, Manuela
Antonilli, Letizia
Togna, Anna Rita
Badiani, Aldo
Saso, Luciano

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-12-28

Country of Publication

Egypt

No. of Pages

14

Main Subjects

Biology

Abstract EN

Oxidative stress (OS) is thought to play an important role in the pharmacological and toxic effects of various drugs of abuse.

Herein we review the literature on the mechanisms responsible for the cardiovascular and hepatic toxicity of cocaine with special focus on OS-related mechanisms.

We also review the preclinical and clinical literature concerning the putative therapeutic effects of OS modulators (such as N-acetylcysteine, superoxide dismutase mimetics, nitroxides and nitrones, NADPH oxidase inhibitors, xanthine oxidase inhibitors, and mitochondriotropic antioxidants) for the treatment of cocaine toxicity.

We conclude that available OS modulators do not appear to have clinical efficacy.

American Psychological Association (APA)

Graziani, Manuela& Antonilli, Letizia& Togna, Anna Rita& Grassi, Maria Caterina& Badiani, Aldo& Saso, Luciano. 2015. Cardiovascular and Hepatic Toxicity of Cocaine: Potential Beneficial Effects of Modulators of Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1114363

Modern Language Association (MLA)

Graziani, Manuela…[et al.]. Cardiovascular and Hepatic Toxicity of Cocaine: Potential Beneficial Effects of Modulators of Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1114363

American Medical Association (AMA)

Graziani, Manuela& Antonilli, Letizia& Togna, Anna Rita& Grassi, Maria Caterina& Badiani, Aldo& Saso, Luciano. Cardiovascular and Hepatic Toxicity of Cocaine: Potential Beneficial Effects of Modulators of Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1114363

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1114363