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Parkin Protects against Oxygen-Glucose DeprivationReperfusion Insult by Promoting Drp1 Degradation
Joint Authors
Zeng, Liuwang
Tang, Jiayu
Tan, Jieqiong
Yang, Sonlin
Hu, Zhiping
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Ischemic stroke results in severe brain damage and remains one of the leading causes of death and disability worldwide.
Effective neuroprotective therapies are needed to reduce brain damage resulting from ischemic stroke.
Mitochondria are crucial for cellular energy production and homeostasis.
Modulation of mitochondrial function mediates neuroprotection against ischemic brain damage.
Dynamin-related protein 1 (Drp1) and parkin play a key role in regulating mitochondrial dynamics.
They are potential therapeutic targets for neuroprotection in ischemic stroke.
Protective effects of parkin-Drp1 pathway on mitochondria were assessed in a cellular ischemia-reperfusion injury model.
Mouse neuroblastoma Neuro2a (N2a) cells were subjected to oxygen-glucose deprivation/reperfusion (OGDR) insult.
OGDR induces mitochondrial fragmentation.
The expression of Drp1 protein is increased after OGDR insult, while the parkin protein level is decreased.
The altered protein level of Drp1 after OGDR injury is mediated by parkin through ubiquitin proteasome system (UPS).
Drp1 depletion protects against OGDR induced mitochondrial damage and apoptosis.
Meanwhile, parkin overexpression protects against OGDR induced apoptosis and mitochondrial dysfunction, which is attenuated by increased expression of Drp1.
Our data demonstrate that parkin protects against OGDR insult through promoting degradation of Drp1.
This neuroprotective potential of parkin-Drp1 pathway against OGDR insult will pave the way for developing novel neuroprotective agents for cerebral ischemia-reperfusion related disorders.
American Psychological Association (APA)
Tang, Jiayu& Hu, Zhiping& Tan, Jieqiong& Yang, Sonlin& Zeng, Liuwang. 2016. Parkin Protects against Oxygen-Glucose DeprivationReperfusion Insult by Promoting Drp1 Degradation. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114376
Modern Language Association (MLA)
Tang, Jiayu…[et al.]. Parkin Protects against Oxygen-Glucose DeprivationReperfusion Insult by Promoting Drp1 Degradation. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1114376
American Medical Association (AMA)
Tang, Jiayu& Hu, Zhiping& Tan, Jieqiong& Yang, Sonlin& Zeng, Liuwang. Parkin Protects against Oxygen-Glucose DeprivationReperfusion Insult by Promoting Drp1 Degradation. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114376
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114376