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Roles of Oxidative Stress in Polycystic Ovary Syndrome and Cancers
Joint Authors
Xu, Wenming
Zuo, Tao
Zhu, Minghui
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-06
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Oxidative stress (OS) has received extensive attention in the last two decades, because of the discovery that abnormal oxidation status was related to patients with chronic diseases, such as diabetes, cardiovascular, polycystic ovary syndrome (PCOS), cancer, and neurological diseases.
OS is considered as a potential inducing factor in the pathogenesis of PCOS, which is one of the most common complex endocrine disorders and a leading cause of female infertility, affecting 4%–12% of women in the world, as OS has close interactions with PCOS characteristics, just as insulin resistance (IR), hyperandrogenemia, and chronic inflammation.
It has also been shown that DNA mutations and alterations induced by OS are involved in cancer pathogenesis, tumor cell survival, proliferation, invasion, angiogenesis, and so on.
Furthermore, recent studies show that the females with PCOS are reported to have an increasing risk of cancers.
As a result, the more serious OS in PCOS is regarded as an important potential incentive for the increasing risk of cancers, and this study aims to analyze the possibility and potential pathogenic mechanism of the above process, providing insightful thoughts and evidences for preventing cancer potentially caused by PCOS in clinic.
American Psychological Association (APA)
Zuo, Tao& Zhu, Minghui& Xu, Wenming. 2015. Roles of Oxidative Stress in Polycystic Ovary Syndrome and Cancers. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1114388
Modern Language Association (MLA)
Zuo, Tao…[et al.]. Roles of Oxidative Stress in Polycystic Ovary Syndrome and Cancers. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1114388
American Medical Association (AMA)
Zuo, Tao& Zhu, Minghui& Xu, Wenming. Roles of Oxidative Stress in Polycystic Ovary Syndrome and Cancers. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1114388
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114388