The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review
Joint Authors
Essa, Musthafa Mohamed
Manoharan, Shanmugam
Abiramasundari, Rajagopal Selladurai
Akbar, Mohammed
Akbar, Mohammed D.
Guillemin, Gilles J.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-27
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Neurodegenerative diseases affect not only the life quality of aging populations, but also their life spans.
All forms of neurodegenerative diseases have a massive impact on the elderly.
The major threat of these brain diseases includes progressive loss of memory, Alzheimer’s disease (AD), impairments in the movement, Parkinson’s disease (PD), and the inability to walk, talk, and think, Huntington’s disease (HD).
Oxidative stress and mitochondrial dysfunction are highlighted as a central feature of brain degenerative diseases.
Oxidative stress, a condition that occurs due to imbalance in oxidant and antioxidant status, has been known to play a vital role in the pathophysiology of neurodegenerative diseases including AD, PD, and HD.
A large number of studies have utilized oxidative stress biomarkers to investigate the severity of these neurodegenerative diseases and medications are available, but these only treat the symptoms.
In traditional medicine, a large number of medicinal plants have been used to treat the symptoms of these neurodegenerative diseases.
Extensive studies scientifically validated the beneficial effect of natural products against neurodegenerative diseases using suitable animal models.
This short review focuses the role of oxidative stress in the pathogenesis of AD, PD, and HD and the protective efficacy of natural products against these diseases.
American Psychological Association (APA)
Manoharan, Shanmugam& Guillemin, Gilles J.& Abiramasundari, Rajagopal Selladurai& Essa, Musthafa Mohamed& Akbar, Mohammed& Akbar, Mohammed D.. 2016. The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1114391
Modern Language Association (MLA)
Manoharan, Shanmugam…[et al.]. The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1114391
American Medical Association (AMA)
Manoharan, Shanmugam& Guillemin, Gilles J.& Abiramasundari, Rajagopal Selladurai& Essa, Musthafa Mohamed& Akbar, Mohammed& Akbar, Mohammed D.. The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1114391
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114391