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Dual Role of ROS as Signal and Stress Agents: Iron Tips the Balance in favor of Toxic Effects
Joint Authors
Gammella, Elena
Recalcati, Stefania
Cairo, Gaetano
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Iron is essential for life, while also being potentially harmful.
Therefore, its level is strictly monitored and complex pathways have evolved to keep iron safely bound to transport or storage proteins, thereby maintaining homeostasis at the cellular and systemic levels.
These sequestration mechanisms ensure that mildly reactive oxygen species like anion superoxide and hydrogen peroxide, which are continuously generated in cells living under aerobic conditions, keep their physiologic role in cell signaling while escaping iron-catalyzed transformation in the highly toxic hydroxyl radical.
In this review, we describe the multifaceted systems regulating cellular and body iron homeostasis and discuss how altered iron balance may lead to oxidative damage in some pathophysiological settings.
American Psychological Association (APA)
Gammella, Elena& Recalcati, Stefania& Cairo, Gaetano. 2016. Dual Role of ROS as Signal and Stress Agents: Iron Tips the Balance in favor of Toxic Effects. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114409
Modern Language Association (MLA)
Gammella, Elena…[et al.]. Dual Role of ROS as Signal and Stress Agents: Iron Tips the Balance in favor of Toxic Effects. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114409
American Medical Association (AMA)
Gammella, Elena& Recalcati, Stefania& Cairo, Gaetano. Dual Role of ROS as Signal and Stress Agents: Iron Tips the Balance in favor of Toxic Effects. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114409
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114409