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Neuroprotection of Grape Seed Extract and Pyridoxine against Triton-Induced Neurotoxicity
Joint Authors
Abdou, Heba M.
Wahby, Mayssaa M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Triton WR-1339 administration causes neurotoxicity.
Natural products and herbal extracts can attenuate cerebral injury.
In the present study, we investigated the neuroprotective role of grape seed extract and/or vitamin B6 against triton-induced neurotoxicity.
Thirty-five adult male albino rats of the Sprague-Dawley strain, weighing 140–145 g, were divided into five groups: control, triton, grape seed extract + triton, grape seed extract + triton + vitamin B6, and vitamin B6 + triton.
The hematological and biochemical analyses were carried out.
Alteration in iNOS mRNA gene expression was determined using reverse-transcriptase PCR analysis.
In addition, qualitative DNA fragmentation was examined using agarose gel electrophoresis.
Triton-treatment caused significant disturbances in the hematological parameters, the neurological functions, and the antioxidant profile.
Also, triton significantly increased the iNOS mRNA expression and DNA damage.
Our results showed that grape seed extract and/or vitamin B6 could attenuate all the examined parameters.
These natural substances could exhibit protective effects against triton-induced neurological damage because of their antioxidative and antiapoptotic capacities.
American Psychological Association (APA)
Abdou, Heba M.& Wahby, Mayssaa M.. 2016. Neuroprotection of Grape Seed Extract and Pyridoxine against Triton-Induced Neurotoxicity. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114423
Modern Language Association (MLA)
Abdou, Heba M.& Wahby, Mayssaa M.. Neuroprotection of Grape Seed Extract and Pyridoxine against Triton-Induced Neurotoxicity. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1114423
American Medical Association (AMA)
Abdou, Heba M.& Wahby, Mayssaa M.. Neuroprotection of Grape Seed Extract and Pyridoxine against Triton-Induced Neurotoxicity. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114423
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114423