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Oxidative Stress during HIV Infection: Mechanisms and Consequences
Joint Authors
Bartosch, Birke
Isaguliants, Maria G.
Ivanova, Olga N.
Valuev-Elliston, Vladimir T.
Kochetkov, Sergey N.
Ivanov, Alexander V.
Starodubova, Elizaveta S.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-13
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
It is generally acknowledged that reactive oxygen species (ROS) play crucial roles in a variety of natural processes in cells.
If increased to levels which cannot be neutralized by the defense mechanisms, they damage biological molecules, alter their functions, and also act as signaling molecules thus generating a spectrum of pathologies.
In this review, we summarize current data on oxidative stress markers associated with human immunodeficiency virus type-1 (HIV-1) infection, analyze mechanisms by which this virus triggers massive ROS production, and describe the status of various defense mechanisms of the infected host cell.
In addition, we have scrutinized scarce data on the effect of ROS on HIV-1 replication.
Finally, we present current state of knowledge on the redox alterations as crucial factors of HIV-1 pathogenicity, such as neurotoxicity and dementia, exhaustion of CD4+/CD8+ T-cells, predisposition to lung infections, and certain side effects of the antiretroviral therapy, and compare them to the pathologies associated with the nitrosative stress.
American Psychological Association (APA)
Ivanov, Alexander V.& Valuev-Elliston, Vladimir T.& Ivanova, Olga N.& Kochetkov, Sergey N.& Starodubova, Elizaveta S.& Bartosch, Birke…[et al.]. 2016. Oxidative Stress during HIV Infection: Mechanisms and Consequences. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1114464
Modern Language Association (MLA)
Ivanov, Alexander V.…[et al.]. Oxidative Stress during HIV Infection: Mechanisms and Consequences. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-18.
https://search.emarefa.net/detail/BIM-1114464
American Medical Association (AMA)
Ivanov, Alexander V.& Valuev-Elliston, Vladimir T.& Ivanova, Olga N.& Kochetkov, Sergey N.& Starodubova, Elizaveta S.& Bartosch, Birke…[et al.]. Oxidative Stress during HIV Infection: Mechanisms and Consequences. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1114464
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114464