Bioactive Peptides from Angelica sinensis Protein Hydrolyzate Delay Senescence in Caenorhabditis elegans through Antioxidant Activities
Joint Authors
Li, Haifeng
Ma, Chung Wah
Huang, Zebo
Wang, Qiangqiang
Huang, Yunxuan
Qin, Chuixin
Liang, Ming
Mao, Xinliang
Li, Shuiming
Zou, Yongdong
Jia, Weizhang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Since excessive reactive oxygen species (ROS) is known to be associated with aging and age-related diseases, strategies modulating ROS level and antioxidant defense systems may contribute to the delay of senescence.
Here we show that the protein hydrolyzate from Angelica sinensis was capable of increasing oxidative survival of the model animal Caenorhabditis elegans intoxicated by paraquat.
The hydrolyzate was then fractionated by ultrafiltration, and the antioxidant fraction (<3 kDa) was purified by gel filtration to obtain the antioxidant A.
sinensis peptides (AsiPeps), which were mostly composed of peptides with <20 amino acid residues.
Further studies demonstrate that AsiPeps were able to reduce the endogenous ROS level, increase the activities of the antioxidant enzymes superoxide dismutase and catalase, and decrease the content of the lipid peroxidation product malondialdehyde in nematodes treated with paraquat or undergoing senescence.
AsiPeps were also shown to reduce age pigments accumulation and extend lifespan but did not affect the food-intake behavior of the nematodes.
Taken together, our results demonstrate that A.
sinensis peptides (AsiPeps) are able to delay aging process in C.
elegans through antioxidant activities independent of dietary restriction.
American Psychological Association (APA)
Wang, Qiangqiang& Huang, Yunxuan& Qin, Chuixin& Liang, Ming& Mao, Xinliang& Li, Shuiming…[et al.]. 2016. Bioactive Peptides from Angelica sinensis Protein Hydrolyzate Delay Senescence in Caenorhabditis elegans through Antioxidant Activities. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114473
Modern Language Association (MLA)
Wang, Qiangqiang…[et al.]. Bioactive Peptides from Angelica sinensis Protein Hydrolyzate Delay Senescence in Caenorhabditis elegans through Antioxidant Activities. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1114473
American Medical Association (AMA)
Wang, Qiangqiang& Huang, Yunxuan& Qin, Chuixin& Liang, Ming& Mao, Xinliang& Li, Shuiming…[et al.]. Bioactive Peptides from Angelica sinensis Protein Hydrolyzate Delay Senescence in Caenorhabditis elegans through Antioxidant Activities. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114473
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114473