Endogenous Sulfur Dioxide: A New Member of Gasotransmitter Family in the Cardiovascular System
Joint Authors
Junbao, D.
Huang, Yaqian
Tang, Chaoshu
Jin, Hongfang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Sulfur dioxide (SO2) was previously regarded as a toxic gas in atmospheric pollutants.
But it has been found to be endogenously generated from metabolism of sulfur-containing amino acids in mammals through transamination by aspartate aminotransferase (AAT).
SO2 could be produced in cardiovascular tissues catalyzed by its synthase AAT.
In recent years, studies revealed that SO2 had physiological effects on the cardiovascular system, including vasorelaxation and cardiac function regulation.
In addition, the pathophysiological effects of SO2 were also determined.
For example, SO2 ameliorated systemic hypertension and pulmonary hypertension, prevented the development of atherosclerosis, and protected against myocardial ischemia-reperfusion (I/R) injury and isoproterenol-induced myocardial injury.
These findings suggested that endogenous SO2 was a novel gasotransmitter in the cardiovascular system and provided a new therapy target for cardiovascular diseases.
American Psychological Association (APA)
Huang, Yaqian& Tang, Chaoshu& Junbao, D.& Jin, Hongfang. 2015. Endogenous Sulfur Dioxide: A New Member of Gasotransmitter Family in the Cardiovascular System. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114477
Modern Language Association (MLA)
Huang, Yaqian…[et al.]. Endogenous Sulfur Dioxide: A New Member of Gasotransmitter Family in the Cardiovascular System. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114477
American Medical Association (AMA)
Huang, Yaqian& Tang, Chaoshu& Junbao, D.& Jin, Hongfang. Endogenous Sulfur Dioxide: A New Member of Gasotransmitter Family in the Cardiovascular System. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114477
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114477