HCV and Oxidative Stress: Implications for HCV Life Cycle and HCV-Associated Pathogenesis
Joint Authors
Medvedev, Regina
Ploen, Daniela
Hildt, Eberhard
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-03
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
HCV (hepatitis C virus) is a member of the Flaviviridae family that contains a single-stranded positive-sense RNA genome of approximately 9600 bases.
HCV is a major causative agent for chronic liver diseases such as steatosis, fibrosis, cirrhosis, and hepatocellular carcinoma which are caused by multifactorial processes.
Elevated levels of reactive oxygen species (ROS) are considered as a major factor contributing to HCV-associated pathogenesis.
This review summarizes the mechanisms involved in formation of ROS in HCV replicating cells and describes the interference of HCV with ROS detoxifying systems.
The relevance of ROS for HCV-associated pathogenesis is reviewed with a focus on the interference of elevated ROS levels with processes controlling liver regeneration.
The overview about the impact of ROS for the viral life cycle is focused on the relevance of autophagy for the HCV life cycle and the crosstalk between HCV, elevated ROS levels, and the induction of autophagy.
American Psychological Association (APA)
Medvedev, Regina& Ploen, Daniela& Hildt, Eberhard. 2016. HCV and Oxidative Stress: Implications for HCV Life Cycle and HCV-Associated Pathogenesis. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114484
Modern Language Association (MLA)
Medvedev, Regina…[et al.]. HCV and Oxidative Stress: Implications for HCV Life Cycle and HCV-Associated Pathogenesis. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1114484
American Medical Association (AMA)
Medvedev, Regina& Ploen, Daniela& Hildt, Eberhard. HCV and Oxidative Stress: Implications for HCV Life Cycle and HCV-Associated Pathogenesis. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114484
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114484