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Studies of the Effectiveness of Bisphosphonate and Vanadium-Bisphosphonate Compounds In Vitro against Axenic Leishmania tarentolae
Joint Authors
Christensen, Amy T.
McLauchlan, Craig C.
Dolbecq, Anne
Mialane, Pierre
Jones, Marjorie A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Leishmaniasis is a disease that is a significant problem for people, especially in tropical regions of the world.
Current drug therapies to treat the disease are expensive, not very effective, and/or of significant side effects.
A series of alkyl bisphosphonate compounds and one amino bisphosphonate compound, as well as alendronate and zoledronate, were tested as potential agents against Leishmania tarentolae.
Also, two polyoxometalates (POMs) with nitrogen-containing bisphosphonate ligands, vanadium/alendronate (V5(Ale)2) and vanadium/zoledronate (V3(Zol)3), were tested against L.
tarentolae and compared to the results of the alendronate and zoledronate ligands alone.
Of the compounds evaluated in this study, the V5(Ale)2 and V3(Zol)3 complexes were most effective in inhibiting the growth of L.
tarentolae.
The V5(Ale)2 complex had a larger impact on cell growth than either alendronate or orthovanadate alone, whereas zoledronate itself has a significant effect on cell growth, which may contribute to the activity of the V3(Zol)3 complex.
American Psychological Association (APA)
Christensen, Amy T.& McLauchlan, Craig C.& Dolbecq, Anne& Mialane, Pierre& Jones, Marjorie A.. 2016. Studies of the Effectiveness of Bisphosphonate and Vanadium-Bisphosphonate Compounds In Vitro against Axenic Leishmania tarentolae. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114657
Modern Language Association (MLA)
Christensen, Amy T.…[et al.]. Studies of the Effectiveness of Bisphosphonate and Vanadium-Bisphosphonate Compounds In Vitro against Axenic Leishmania tarentolae. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1114657
American Medical Association (AMA)
Christensen, Amy T.& McLauchlan, Craig C.& Dolbecq, Anne& Mialane, Pierre& Jones, Marjorie A.. Studies of the Effectiveness of Bisphosphonate and Vanadium-Bisphosphonate Compounds In Vitro against Axenic Leishmania tarentolae. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114657
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114657