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Demethoxycurcumin Preserves Renovascular Function by Downregulating COX-2 Expression in Hypertension
Joint Authors
Li, Yingjuan
Tian, Danyang
Zhu, Chunhua
Ren, Liqun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hypertension-associated endothelial dysfunction is largely due to the exaggerated vasoconstrictor generation by cyclooxygenase-2 (COX-2).
COX-2 is induced under inflammatory condition.
Demethoxycurcumin (DMC) is a major component of Curcuma longa L, which possesses anti-inflammatory action.
This study aimed to examine whether DMC protects endothelial function in hypertension by modulating COX-2.
Changes in isometric tension showed that in vivo and ex vivo treatment with DMC rescued the attenuated endothelium-dependent relaxations (EDRs) and elevated endothelium-dependent contractions (EDCs) in the renal arteries of SHR, which were also corrected by acute usage of the COX-2 inhibitor celecoxib.
The restoration of renovascular activity by DMC was accompanied by the normalization of COX-2 expression.
The enhanced COX-2 expression observed in the renal arteries of hypertensive patients was suppressed by incubation of excised arteries with DMC for 12 hrs.
In the renal arteries of Wistar-Kyoto rats (WKY), DMC prevented the endothelial dysfunction caused by angiotensin II.
The reduction in the generation of nitric oxide (NO) and expression of eNOS phosphorylation (Ser1177) in human umbilical vein endothelial cells caused by angiotensin II (Ang II) were restored by DMC or celecoxib.
Our findings suggest that DMC may decrease COX-2 expression and improve endothelial function in hypertension.
American Psychological Association (APA)
Li, Yingjuan& Tian, Danyang& Zhu, Chunhua& Ren, Liqun. 2016. Demethoxycurcumin Preserves Renovascular Function by Downregulating COX-2 Expression in Hypertension. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114659
Modern Language Association (MLA)
Li, Yingjuan…[et al.]. Demethoxycurcumin Preserves Renovascular Function by Downregulating COX-2 Expression in Hypertension. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1114659
American Medical Association (AMA)
Li, Yingjuan& Tian, Danyang& Zhu, Chunhua& Ren, Liqun. Demethoxycurcumin Preserves Renovascular Function by Downregulating COX-2 Expression in Hypertension. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114659
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114659