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Mitochondria in the Aging Muscles of Flies and Mice: New Perspectives for Old Characters
Joint Authors
Campo, Andrea del
Jaimovich, Enrique
Tevy, Maria Florencia
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Sarcopenia is the loss of muscle mass accompanied by a decrease in muscle strength and resistance and is the main cause of disability among the elderly.
Muscle loss begins long before there is any clear physical impact in the senior adult.
Despite all this, the molecular mechanisms underlying muscle aging are far from being understood.
Recent studies have identified that not only mitochondrial metabolic dysfunction but also mitochondrial dynamics and mitochondrial calcium uptake could be involved in the degeneration of skeletal muscle mass.
Mitochondrial homeostasis influences muscle quality which, in turn, could play a triggering role in signaling of systemic aging.
Thus, it has become apparent that mitochondrial status in muscle cells could be a driver of whole body physiology and organismal aging.
In the present review, we discuss the existing evidence for the mitochondria related mechanisms underlying the appearance of muscle aging and sarcopenia in flies and mice.
American Psychological Association (APA)
Campo, Andrea del& Jaimovich, Enrique& Tevy, Maria Florencia. 2016. Mitochondria in the Aging Muscles of Flies and Mice: New Perspectives for Old Characters. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114670
Modern Language Association (MLA)
Campo, Andrea del…[et al.]. Mitochondria in the Aging Muscles of Flies and Mice: New Perspectives for Old Characters. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1114670
American Medical Association (AMA)
Campo, Andrea del& Jaimovich, Enrique& Tevy, Maria Florencia. Mitochondria in the Aging Muscles of Flies and Mice: New Perspectives for Old Characters. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114670
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114670