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Hydrogen Sulfide Improves Vascular Calcification in Rats by Inhibiting Endoplasmic Reticulum Stress
Joint Authors
Xiao, Lin
Xue, Hong-Mei
Guo, Qi
Teng, Xu
Wu, Yu-Ming
Yang, Rui
Li, Hui
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In this study, the vitamin D3 plus nicotine (VDN) model of rats was used to prove that H2S alleviates vascular calcification (VC) and phenotype transformation of vascular smooth muscle cells (VSMC).
Besides, H2S can also inhibit endoplasmic reticulum stress (ERS) of calcified aortic tissues.
The effect of H2S on alleviating VC and phenotype transformation of VSMC can be blocked by TM, while PBA also alleviated VC and phenotype transformation of VSMC that was similar to the effect of H2S.
These results suggest that H2S may alleviate rat aorta VC by inhibiting ERS, providing new target and perspective for prevention and treatment of VC.
American Psychological Association (APA)
Yang, Rui& Teng, Xu& Li, Hui& Xue, Hong-Mei& Guo, Qi& Xiao, Lin…[et al.]. 2016. Hydrogen Sulfide Improves Vascular Calcification in Rats by Inhibiting Endoplasmic Reticulum Stress. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114682
Modern Language Association (MLA)
Yang, Rui…[et al.]. Hydrogen Sulfide Improves Vascular Calcification in Rats by Inhibiting Endoplasmic Reticulum Stress. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114682
American Medical Association (AMA)
Yang, Rui& Teng, Xu& Li, Hui& Xue, Hong-Mei& Guo, Qi& Xiao, Lin…[et al.]. Hydrogen Sulfide Improves Vascular Calcification in Rats by Inhibiting Endoplasmic Reticulum Stress. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114682
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114682