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Serum Superoxide Dismutase Is Associated with Vascular Structure and Function in Hypertensive and Diabetic Patients
Joint Authors
Martinez-Salgado, C.
Gómez-Marcos, Manuel A.
Blázquez-Medela, Ana M.
Gamella-Pozuelo, Luis
Recio-Rodriguez, José I.
García-Ortiz, Luis
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Oxidative stress is associated with cardiac and vascular defects leading to hypertension and atherosclerosis, being superoxide dismutase (SOD) one of the main intracellular antioxidant defence mechanisms.
Although several parameters of vascular function and structure have a predictive value for cardiovascular morbidity-mortality in hypertensive patients, there are no studies on the involvement of SOD serum levels with these vascular parameters.
Thus, we assessed if SOD serum levels are correlated with parameters of vascular function and structure and with cardiovascular risk in hypertensive and type 2 diabetic patients.
We enrolled 255 consecutive hypertensive and diabetic patients and 52 nondiabetic and nonhypertensive controls.
SOD levels were measured with an enzyme-linked immunosorbent assay kit.
Vascular function and structure were evaluated by pulse wave velocity, augmentation index, ambulatory arterial stiffness index, and carotid intima-media thickness.
We detected negative correlations between SOD and pressure wave velocity, peripheral and central augmentation index and ambulatory arterial stiffness index, pulse pressure, and plasma HDL-cholesterol, as well as positive correlations between SOD and plasma uric acid and triglycerides.
Our study shows that SOD is a marker of cardiovascular alterations in hypertensive and diabetic patients, since changes in its serum levels are correlated with alterations in vascular structure and function.
American Psychological Association (APA)
Gómez-Marcos, Manuel A.& Blázquez-Medela, Ana M.& Gamella-Pozuelo, Luis& Recio-Rodriguez, José I.& García-Ortiz, Luis& Martinez-Salgado, C.. 2015. Serum Superoxide Dismutase Is Associated with Vascular Structure and Function in Hypertensive and Diabetic Patients. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114698
Modern Language Association (MLA)
Gómez-Marcos, Manuel A.…[et al.]. Serum Superoxide Dismutase Is Associated with Vascular Structure and Function in Hypertensive and Diabetic Patients. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1114698
American Medical Association (AMA)
Gómez-Marcos, Manuel A.& Blázquez-Medela, Ana M.& Gamella-Pozuelo, Luis& Recio-Rodriguez, José I.& García-Ortiz, Luis& Martinez-Salgado, C.. Serum Superoxide Dismutase Is Associated with Vascular Structure and Function in Hypertensive and Diabetic Patients. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114698
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114698