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Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes
Joint Authors
Marinić, Jelena
Broznić, Dalibor
Milin, Čedomila
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Polyphenols can act as oxidants in some conditions, inducing redox-sensitive genes.
We investigated the effect of preexposure to the olive oil polyphenols extract (PFE) on time-dependent changes in the hepatic oxidative state in a model of liver regeneration—a process in which oxidative stress associated with the metabolic overload accounts for the early events that contribute to the onset of liver self-repair.
Liver regeneration was induced by one-third hepatectomy in mice.
Prior to hepatectomy, mice were intraperitoneally given either PFE (50 mg/kg body weight) or saline for seven consecutive days, while respective controls received vehicle alone.
Redox state-regulating enzymes and thiol proteins along with the mRNA levels of Nrf2 gene and its targets γ -glutamylcysteine synthetase and heme oxygenase-1 were determined at different time intervals after hepatectomy.
The liver mass restoration was calculated to assess hepatic regeneration.
The resulting data demonstrate the effectiveness of preexposure to PFE in stimulating liver regeneration in a model of a small tissue loss which may be ascribed to the transient increase in oxidant load during the first hours after hepatectomy and associated induction of stress response gene-profiles under the control of Nrf2.
American Psychological Association (APA)
Marinić, Jelena& Broznić, Dalibor& Milin, Čedomila. 2016. Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114718
Modern Language Association (MLA)
Marinić, Jelena…[et al.]. Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1114718
American Medical Association (AMA)
Marinić, Jelena& Broznić, Dalibor& Milin, Čedomila. Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114718
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114718