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Maresin 1, a Proresolving Lipid Mediator, Mitigates Carbon Tetrachloride-Induced Liver Injury in Mice
Joint Authors
Zhao, Ende
Li, Ruidong
Wang, Yaxin
Wang, Di
Xie, Gengchen
Yin, Yuping
Zhang, Peng
Wu, Ke
Li, Wei
Shi, Liang
Deng, Meizhou
Tao, Kaixiong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Maresin 1 (MaR 1) was recently reported to have protective properties in several different animal models of acute inflammation by inhibiting inflammatory response.
However, its function in acute liver injury is still unknown.
To address this question, we induced liver injury in BALB/c mice with intraperitoneal injection of carbon tetrachloride with or without treatment of MaR 1.
Our data showed that MaR 1 attenuated hepatic injury, oxidative stress, and lipid peroxidation induced by carbon tetrachloride, as evidenced by increased thiobarbituric acid reactive substances and reactive oxygen species levels were inhibited by treatment of MaR 1.
Furthermore, MaR 1 increased activities of antioxidative mediators in carbon tetrachloride-treated mice liver.
MaR 1 decreased indices of inflammatory mediators such as tumor necrosis factor-α, interleukin-6, interleukin-1β, monocyte chemotactic protein 1, myeloperoxidase, cyclooxygenase-2, and inducible nitric oxide synthase.
Administration of MaR 1 inhibited activation of nuclear factor kappa B (NF-κb) and mitogen-activated protein kinases (MAPKs) in the liver of CCl4 treated mice.
In conclusion, these results suggested the antioxidative, anti-inflammatory properties of MaR 1 in CCl4 induced liver injury.
The possible mechanism is partly implicated in its abilities to inhibit ROS generation and activation of NF-κb and MAPK pathway.
American Psychological Association (APA)
Li, Ruidong& Wang, Yaxin& Zhao, Ende& Wu, Ke& Li, Wei& Shi, Liang…[et al.]. 2016. Maresin 1, a Proresolving Lipid Mediator, Mitigates Carbon Tetrachloride-Induced Liver Injury in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114721
Modern Language Association (MLA)
Li, Ruidong…[et al.]. Maresin 1, a Proresolving Lipid Mediator, Mitigates Carbon Tetrachloride-Induced Liver Injury in Mice. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1114721
American Medical Association (AMA)
Li, Ruidong& Wang, Yaxin& Zhao, Ende& Wu, Ke& Li, Wei& Shi, Liang…[et al.]. Maresin 1, a Proresolving Lipid Mediator, Mitigates Carbon Tetrachloride-Induced Liver Injury in Mice. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114721
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114721