Therapeutic Potential of Curcumin for the Treatment of Brain Tumors
Joint Authors
Mittal, Sandeep
Klinger, Neil V.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-11
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Brain malignancies currently carry a poor prognosis despite the current multimodal standard of care that includes surgical resection and adjuvant chemotherapy and radiation.
As new therapies are desperately needed, naturally occurring chemical compounds have been studied for their potential chemotherapeutic benefits and low toxicity profile.
Curcumin, found in the rhizome of turmeric, has extensive therapeutic promise via its antioxidant, anti-inflammatory, and antiproliferative properties.
Preclinical in vitro and in vivo data have shown it to be an effective treatment for brain tumors including glioblastoma multiforme.
These effects are potentiated by curcumin’s ability to induce G2/M cell cycle arrest, activation of apoptotic pathways, induction of autophagy, disruption of molecular signaling, inhibition of invasion, and metastasis and by increasing the efficacy of existing chemotherapeutics.
Further, clinical data suggest that it has low toxicity in humans even at large doses.
Curcumin is a promising nutraceutical compound that should be evaluated in clinical trials for the treatment of human brain tumors.
American Psychological Association (APA)
Klinger, Neil V.& Mittal, Sandeep. 2016. Therapeutic Potential of Curcumin for the Treatment of Brain Tumors. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1114750
Modern Language Association (MLA)
Klinger, Neil V.& Mittal, Sandeep. Therapeutic Potential of Curcumin for the Treatment of Brain Tumors. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1114750
American Medical Association (AMA)
Klinger, Neil V.& Mittal, Sandeep. Therapeutic Potential of Curcumin for the Treatment of Brain Tumors. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1114750
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114750