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Cell Death and Heart Failure in Obesity: Role of Uncoupling Proteins
Joint Authors
Ruiz-Ramírez, Angélica
López-Acosta, Ocarol
Barrios-Maya, Miguel Angel
El-Hafidi, Mohammed
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Metabolic diseases such as obesity, metabolic syndrome, and type II diabetes are often characterized by increased reactive oxygen species (ROS) generation in mitochondrial respiratory complexes, associated with fat accumulation in cardiomyocytes, skeletal muscle, and hepatocytes.
Several rodents studies showed that lipid accumulation in cardiac myocytes produces lipotoxicity that causes apoptosis and leads to heart failure, a dynamic pathological process.
Meanwhile, several tissues including cardiac tissue develop an adaptive mechanism against oxidative stress and lipotoxicity by overexpressing uncoupling proteins (UCPs), specific mitochondrial membrane proteins.
In heart from rodent and human with obesity, UCP2 and UCP3 may protect cardiomyocytes from death and from a state progressing to heart failure by downregulating programmed cell death.
UCP activation may affect cytochrome c and proapoptotic protein release from mitochondria by reducing ROS generation and apoptotic cell death.
Therefore the aim of this review is to discuss recent findings regarding the role that UCPs play in cardiomyocyte survival by protecting against ROS generation and maintaining bioenergetic metabolism homeostasis to promote heart protection.
American Psychological Association (APA)
Ruiz-Ramírez, Angélica& López-Acosta, Ocarol& Barrios-Maya, Miguel Angel& El-Hafidi, Mohammed. 2016. Cell Death and Heart Failure in Obesity: Role of Uncoupling Proteins. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114753
Modern Language Association (MLA)
Ruiz-Ramírez, Angélica…[et al.]. Cell Death and Heart Failure in Obesity: Role of Uncoupling Proteins. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1114753
American Medical Association (AMA)
Ruiz-Ramírez, Angélica& López-Acosta, Ocarol& Barrios-Maya, Miguel Angel& El-Hafidi, Mohammed. Cell Death and Heart Failure in Obesity: Role of Uncoupling Proteins. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114753
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114753