Effects of Astragalus Polysaccharides on Dysfunction of Mitochondrial Dynamics Induced by Oxidative Stress
Joint Authors
Huang, Yan-Feng
Zhu, Da-Jian
Lu, Lu
Lu, Lu
Wang, Ming
Yin, Yi
Chen, De-Xiu
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-11
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
This paper studied the chronic fatigue induced by excessive exercise and the restoration effects of Astragalus polysaccharides (APS) on mitochondria.
In vivo, we found that excessive exercise could cause oxidative stress statue which led to morphological and functional changes of mitochondria.
The changes, including imbalance between mitochondria fusion-fission processes, activation of mitophagy, and decrease of PGC-1α expression, could be restored by APS.
We further confirmed in vitro, and what is more, we found that APS may ameliorate mitochondrial dysfunction through Sirt1 pathway.
Based on the results, we may figure out part of the molecular mechanism of mitochondrial amelioration by APS.
American Psychological Association (APA)
Huang, Yan-Feng& Lu, Lu& Zhu, Da-Jian& Wang, Ming& Yin, Yi& Chen, De-Xiu…[et al.]. 2016. Effects of Astragalus Polysaccharides on Dysfunction of Mitochondrial Dynamics Induced by Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114787
Modern Language Association (MLA)
Huang, Yan-Feng…[et al.]. Effects of Astragalus Polysaccharides on Dysfunction of Mitochondrial Dynamics Induced by Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1114787
American Medical Association (AMA)
Huang, Yan-Feng& Lu, Lu& Zhu, Da-Jian& Wang, Ming& Yin, Yi& Chen, De-Xiu…[et al.]. Effects of Astragalus Polysaccharides on Dysfunction of Mitochondrial Dynamics Induced by Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114787
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114787