Nr2e1 Deficiency Augments Palmitate-Induced Oxidative Stress in Beta Cells
Joint Authors
Deng, Haohua
Dai, Zhe
Xu, Yancheng
Xiong, Xiaokan
Ma, Pei
Cheng, Jing
Shi, Xiao-li
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Nuclear receptor subfamily 2 group E member 1 (Nr2e1) has been regarded as an essential regulator of the growth of neural stem cells.
However, its function elsewhere is unknown.
In the present study, we generated Nr2e1 knockdown MIN6 cells and studied whether Nr2e1 knockdown affected basal beta cell functions such as proliferation, cell death, and insulin secretion.
We showed that knockdown of Nr2e1 in MIN6 cells resulted in increased sensitivity to lipotoxicity, decreased proliferation, a partial G0/G1 cell-cycle arrest, and higher rates of apoptosis.
Moreover, Nr2e1 deficiency exaggerates palmitate-induced impairment in insulin secretion.
At the molecular level, Nr2e1 deficiency augments palmitate-induced oxidative stress.
Nr2e1 deficiency also resulted in decreases in antioxidant enzymes and expression level of Nrf2.
Together, this study indicated a potential protective effect of Nr2e1 on beta cells, which may serve as a target for the development of novel therapies for diabetes.
American Psychological Association (APA)
Shi, Xiao-li& Deng, Haohua& Dai, Zhe& Xu, Yancheng& Xiong, Xiaokan& Ma, Pei…[et al.]. 2015. Nr2e1 Deficiency Augments Palmitate-Induced Oxidative Stress in Beta Cells. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114799
Modern Language Association (MLA)
Shi, Xiao-li…[et al.]. Nr2e1 Deficiency Augments Palmitate-Induced Oxidative Stress in Beta Cells. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114799
American Medical Association (AMA)
Shi, Xiao-li& Deng, Haohua& Dai, Zhe& Xu, Yancheng& Xiong, Xiaokan& Ma, Pei…[et al.]. Nr2e1 Deficiency Augments Palmitate-Induced Oxidative Stress in Beta Cells. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114799
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114799