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Resveratrol: A Potential Hippocampal Plasticity Enhancer
Joint Authors
Thuret, Sandrine
Cocks, Graham
Dias, Gisele Pereira
Nardi, Antonio Egidio
do Nascimento Bevilaqua, Mário Cesar
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-25
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The search for molecules capable of restoring altered hippocampal plasticity in psychiatric and neurological conditions is one of the most important tasks of modern neuroscience.
It is well established that neural plasticity, such as the ability of the postnatal hippocampus to continuously generate newly functional neurons throughout life, a process called adult hippocampal neurogenesis (AHN), can be modulated not only by pharmacological agents, physical exercise, and environmental enrichment, but also by “nutraceutical” agents.
In this review we focus on resveratrol, a phenol and phytoalexin found in the skin of grapes and red berries, as well as in nuts.
Resveratrol has been reported to have antioxidant and antitumor properties, but its effects as a neural plasticity inducer are still debated.
The current review examines recent evidence implicating resveratrol in regulating hippocampal neural plasticity and in mitigating the effects of various disorders and diseases on this important brain structure.
Overall, findings show that resveratrol can improve cognition and mood and enhance hippocampal plasticity and AHN; however, some studies report opposite effects, with resveratrol inhibiting aspects of AHN.
Therefore, further investigation is needed to resolve these controversies before resveratrol can be established as a safe coadjuvant in preventing and treating neuropsychiatric conditions.
American Psychological Association (APA)
Dias, Gisele Pereira& Cocks, Graham& do Nascimento Bevilaqua, Mário Cesar& Nardi, Antonio Egidio& Thuret, Sandrine. 2016. Resveratrol: A Potential Hippocampal Plasticity Enhancer. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1114801
Modern Language Association (MLA)
Dias, Gisele Pereira…[et al.]. Resveratrol: A Potential Hippocampal Plasticity Enhancer. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1114801
American Medical Association (AMA)
Dias, Gisele Pereira& Cocks, Graham& do Nascimento Bevilaqua, Mário Cesar& Nardi, Antonio Egidio& Thuret, Sandrine. Resveratrol: A Potential Hippocampal Plasticity Enhancer. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1114801
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114801