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Oxidative Stress Markers and Their Dynamic Changes in Patients after Acute Ischemic Stroke
Joint Authors
Turčáni, Peter
Laubertova, Lucia
Žitňanová, Ingrid
Šiarnik, Pavol
Kollár, Branislav
Chomová, Mária
Pazderová, Petra
Andrezálová, Lucia
Ježovičová, Miriam
Koňariková, Katarína
Krivošíková, Zuzana
Slezáková, Laura
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We have focused on determining the range of oxidative stress biomarkers and their dynamic changes in patients at different time points after the acute ischemic stroke (AIS).
82 patients with AIS were involved in our study and were tested: within 24 h from the onset of the attack (group A); at 7-day follow-up (group B); and at 3-month follow-up (group C).
81 gender and age matched volunteers were used as controls.
Stroke patients in group A had significantly higher concentrations of plasma lipid peroxides and urine 8-isoprostanes when compared with controls.
Protein carbonyls were not significantly different in any experimental group compared to controls.
Antioxidant capacity of plasma was increased only in experimental group C.
Activities of superoxide dismutase and catalase were elevated in all three experimental AIS groups compared to controls.
Paraoxonase activity was reduced in groups A and B and unchanged in group C when compared to controls.
Glutathione peroxide activity was elevated only in group A.
Our results suggest that free radical damage is the highest within 24 h after the attack.
During the next 3 months oxidative damage to lipids caused by free radicals is reduced due to activated antioxidant system.
American Psychological Association (APA)
Žitňanová, Ingrid& Šiarnik, Pavol& Kollár, Branislav& Chomová, Mária& Pazderová, Petra& Andrezálová, Lucia…[et al.]. 2016. Oxidative Stress Markers and Their Dynamic Changes in Patients after Acute Ischemic Stroke. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1114817
Modern Language Association (MLA)
Žitňanová, Ingrid…[et al.]. Oxidative Stress Markers and Their Dynamic Changes in Patients after Acute Ischemic Stroke. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1114817
American Medical Association (AMA)
Žitňanová, Ingrid& Šiarnik, Pavol& Kollár, Branislav& Chomová, Mária& Pazderová, Petra& Andrezálová, Lucia…[et al.]. Oxidative Stress Markers and Their Dynamic Changes in Patients after Acute Ischemic Stroke. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1114817
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114817