A Case-Control Study on the Oxidative Balance of 50% Autologous Serum Eye Drops
Joint Authors
Belló-Klein, Adriane
Campos, Cristina
Fernandes, Tânia R. G.
Gus, Patrícia Ioschpe
Marinho, Diane
Zelanis, Samira
Locatelli, Claudete
Nicola, Felipe
Kunzler, Ana Laura
Barbosa, Luciene
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Importance.
Autologous serum (AS) eye drops are recommended for severe dry eye in patients with ocular surface disease.
No description of the antioxidant balance of AS eye drops has been reported in the literature.
Objective.
This study sought to evaluate the total reactive antioxidant potential (TRAP) and concentration of reactive oxygen species (ROS) in samples of 50% AS eye drops and their correlations with the demographic characteristics and lifestyle habits of patients with ocular surface disease and healthy controls.
Design.
This was a case-control study with a 3-month follow-up period.
Participants.
16 patients with severe dry eye disease of different etiologies and 17 healthy controls matched by age, gender, and race were included.
Results.
TRAP and ROS were detected at all evaluated times.
There were no differences in the mean ROS ( p = 0.429 ) or TRAP ( p = 0.475 ) levels between cases and controls.
No statistically significant differences in the concentrations of ROS or TRAPs were found at 0, 15, or 30 days ( p for ROS = 0.087 and p for TRAP = 0.93).
Neither the demographic characteristics nor the lifestyle habits were correlated with the oxidative balance of the 50% AS eye drops.
Conclusions and Relevance.
Both fresh and frozen 50% AS eye drops present antioxidant capacities and ROS in an apparently stable balance.
Moreover, patients with ocular surface disease and normal controls produce equivalent AS eye drops in terms of oxidative properties.
American Psychological Association (APA)
Gus, Patrícia Ioschpe& Marinho, Diane& Zelanis, Samira& Belló-Klein, Adriane& Locatelli, Claudete& Nicola, Felipe…[et al.]. 2016. A Case-Control Study on the Oxidative Balance of 50% Autologous Serum Eye Drops. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1114826
Modern Language Association (MLA)
Gus, Patrícia Ioschpe…[et al.]. A Case-Control Study on the Oxidative Balance of 50% Autologous Serum Eye Drops. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1114826
American Medical Association (AMA)
Gus, Patrícia Ioschpe& Marinho, Diane& Zelanis, Samira& Belló-Klein, Adriane& Locatelli, Claudete& Nicola, Felipe…[et al.]. A Case-Control Study on the Oxidative Balance of 50% Autologous Serum Eye Drops. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1114826
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114826