Intermittent Hypoxia-Induced Carotid Body Chemosensory Potentiation and Hypertension Are Critically Dependent on Peroxynitrite Formation
Joint Authors
Del Rio, Rodrigo
Moya, Esteban A.
Arias, Paulina
Varela, Carlos
Oyarce, María P.
Iturriaga, Rodrigo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Oxidative stress is involved in the development of carotid body (CB) chemosensory potentiation and systemic hypertension induced by chronic intermittent hypoxia (CIH), the main feature of obstructive sleep apnea.
We tested whether peroxynitrite (ONOO−), a highly reactive nitrogen species, is involved in the enhanced CB oxygen chemosensitivity and the hypertension during CIH.
Accordingly, we studied effects of Ebselen, an ONOO− scavenger, on 3-nitrotyrosine immunoreactivity (3-NT-ir) in the CB, the CB chemosensory discharge, and arterial blood pressure (BP) in rats exposed to CIH.
Male Sprague-Dawley rats were exposed to CIH (5% O2, 12 times/h, 8 h/day) for 7 days.
Ebselen (10 mg/kg/day) was administrated using osmotic minipumps and BP measured with radiotelemetry.
Compared to the sham animals, CIH-treated rats showed increased 3-NT-ir within the CB, enhanced CB chemosensory responses to hypoxia, increased BP response to acute hypoxia, and hypertension.
Rats treated with Ebselen and exposed to CIH displayed a significant reduction in 3-NT-ir levels (60.8 ± 14.9 versus 22.9 ± 4.2 a.u.), reduced CB chemosensory response to 5% O2 (266.5 ± 13.4 versus 168.6 ± 16.8 Hz), and decreased mean BP (116.9 ± 13.2 versus 82.1 ± 5.1 mmHg).
Our results suggest that CIH-induced CB chemosensory potentiation and hypertension are critically dependent on ONOO− formation.
American Psychological Association (APA)
Moya, Esteban A.& Arias, Paulina& Varela, Carlos& Oyarce, María P.& Del Rio, Rodrigo & Iturriaga, Rodrigo. 2015. Intermittent Hypoxia-Induced Carotid Body Chemosensory Potentiation and Hypertension Are Critically Dependent on Peroxynitrite Formation. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114840
Modern Language Association (MLA)
Moya, Esteban A.…[et al.]. Intermittent Hypoxia-Induced Carotid Body Chemosensory Potentiation and Hypertension Are Critically Dependent on Peroxynitrite Formation. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114840
American Medical Association (AMA)
Moya, Esteban A.& Arias, Paulina& Varela, Carlos& Oyarce, María P.& Del Rio, Rodrigo & Iturriaga, Rodrigo. Intermittent Hypoxia-Induced Carotid Body Chemosensory Potentiation and Hypertension Are Critically Dependent on Peroxynitrite Formation. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114840
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114840