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The Regulatory Role of Nuclear Factor Kappa B in the Heart of Hereditary Hypertriglyceridemic Rat
Joint Authors
Pecháňová, Olga
Vranková, Stanislava
Klimentová, Jana
Dobešová, Zdenka
Kuneš, Jaroslav
Dovinová, Ima
Barta, Andrej
Zicha, Josef
Liskova, Silvia
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Activation of nuclear factor-κB (NF-κB) by increased production of reactive oxygen species (ROS) might induce transcription and expression of different antioxidant enzymes and also of nitric oxide synthase (NOS) isoforms.
Thus, we aimed at studying the effect of NF-κB inhibition, caused by JSH-23 (4-methyl- N 1 -(3-phenyl-propyl)-benzene-1,2-diamine) injection, on ROS and NO generation in hereditary hypertriglyceridemic (HTG) rats.
12-week-old, male Wistar and HTG rats were treated with JSH-23 (bolus, 10 μmol, i.v.).
After one week, blood pressure (BP), superoxide dismutase (SOD) activity, SOD1, endothelial NOS (eNOS), and NF-κB (p65) protein expressions were higher in the heart of HTG rats compared to control rats.
On the other hand, NOS activity was decreased.
In HTG rats, JSH-23 treatment increased BP and heart conjugated dienes (CD) concentration (measured as the marker of tissue oxidative damage).
Concomitantly, SOD activity together with SOD1 expression was decreased, while NOS activity and eNOS protein expression were increased significantly.
In conclusion, NF-κB inhibition in HTG rats led to decreased ROS degradation by SOD followed by increased oxidative damage in the heart and BP elevation.
In these conditions, increased NO generation may represent rather a counterregulatory mechanism activated by ROS.
Nevertheless, this mechanism was not sufficient enough to compensate BP increase in HTG rats.
American Psychological Association (APA)
Vranková, Stanislava& Barta, Andrej& Klimentová, Jana& Dovinová, Ima& Liskova, Silvia& Dobešová, Zdenka…[et al.]. 2016. The Regulatory Role of Nuclear Factor Kappa B in the Heart of Hereditary Hypertriglyceridemic Rat. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1114843
Modern Language Association (MLA)
Vranková, Stanislava…[et al.]. The Regulatory Role of Nuclear Factor Kappa B in the Heart of Hereditary Hypertriglyceridemic Rat. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1114843
American Medical Association (AMA)
Vranková, Stanislava& Barta, Andrej& Klimentová, Jana& Dovinová, Ima& Liskova, Silvia& Dobešová, Zdenka…[et al.]. The Regulatory Role of Nuclear Factor Kappa B in the Heart of Hereditary Hypertriglyceridemic Rat. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1114843
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114843