Activation of Antioxidative Functions by Radon Inhalation Enhances the Mitigation Effects of Pregabalin on Chronic Constriction Injury-Induced Neuropathic Pain in Mice
Joint Authors
Yamaoka, Kiyonori
Horie, Shunsuke
Etani, Reo
Kanzaki, Norie
Sasaoka, Kaori
Kobashi, Yusuke
Hanamoto, Katsumi
Kataoka, Takahiro
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Radon inhalation brings pain relief for chronic constriction injury- (CCI-) induced neuropathic pain in mice due to the activation of antioxidative functions, which is different from the mechanism of the pregabalin effect.
In this study, we assessed whether a combination of radon inhalation and pregabalin administration is more effective against neuropathic pain than radon or pregabalin only.
Mice were treated with inhaled radon at a concentration of 1,000 Bq/m3 for 24 hours and pregabalin administration after CCI surgery.
In mice treated with pregabalin at a dose of 3 mg/kg weight, the 50% paw withdrawal threshold of mice treated with pregabalin or radon and pregabalin was significantly increased, suggesting pain relief.
The therapeutic effects of radon inhalation or the combined effects of radon and pregabalin (3 mg/kg weight) were almost equivalent to treatment with pregabalin at a dose of 1.4 mg/kg weight or 4.1 mg/kg weight, respectively.
Radon inhalation and the combination of radon and pregabalin increased antioxidant associated substances in the paw.
The antioxidant substances increased much more in radon inhalation than in pregabalin administration.
These findings suggested that the activation of antioxidative functions by radon inhalation enhances the pain relief of pregabalin and that this combined effect is probably an additive effect.
American Psychological Association (APA)
Kataoka, Takahiro& Horie, Shunsuke& Etani, Reo& Kanzaki, Norie& Sasaoka, Kaori& Kobashi, Yusuke…[et al.]. 2015. Activation of Antioxidative Functions by Radon Inhalation Enhances the Mitigation Effects of Pregabalin on Chronic Constriction Injury-Induced Neuropathic Pain in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114864
Modern Language Association (MLA)
Kataoka, Takahiro…[et al.]. Activation of Antioxidative Functions by Radon Inhalation Enhances the Mitigation Effects of Pregabalin on Chronic Constriction Injury-Induced Neuropathic Pain in Mice. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1114864
American Medical Association (AMA)
Kataoka, Takahiro& Horie, Shunsuke& Etani, Reo& Kanzaki, Norie& Sasaoka, Kaori& Kobashi, Yusuke…[et al.]. Activation of Antioxidative Functions by Radon Inhalation Enhances the Mitigation Effects of Pregabalin on Chronic Constriction Injury-Induced Neuropathic Pain in Mice. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114864
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114864