Prostate Radiotherapy in the Era of Advanced Imaging and Precision Medicine
Joint Authors
Rais-Bahrami, Soroush
Yang, Eddy S.
Dulaney, Caleb R.
Osula, Daniel O.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Tremendous technological advancements in prostate radiotherapy have decreased treatment toxicity and improved clinical outcomes for men with prostate cancer.
While these advances have allowed for significant treatment volume reduction and whole-organ dose escalation, further improvement in prostate radiotherapy has been limited by classic techniques for diagnosis and risk stratification.
Developments in prostate imaging, image-guided targeted biopsy, next-generation gene expression profiling, and targeted molecular therapies now provide information to stratify patients and select treatments based on tumor biology.
Image-guided targeted biopsy improves detection of clinically significant cases of prostate cancer and provides important information about the biological behavior of intraprostatic lesions which can further guide treatment decisions.
We review the evolution of prostate magnetic resonance imaging (MRI) and MRI-ultrasound fusion-guided prostate biopsy.
Recent advancements in radiation therapy including dose escalation, moderate and extreme hypofractionation, partial prostate radiation therapy, and finally dose escalation by simultaneous integrated boost are discussed.
We also review next-generation sequencing and discuss developments in targeted molecular therapies.
Last, we review ongoing clinical trials and future treatment paradigms that integrate targeted biopsy, molecular profiling and therapy, and prostate radiotherapy.
American Psychological Association (APA)
Dulaney, Caleb R.& Osula, Daniel O.& Yang, Eddy S.& Rais-Bahrami, Soroush. 2016. Prostate Radiotherapy in the Era of Advanced Imaging and Precision Medicine. Prostate Cancer،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114891
Modern Language Association (MLA)
Dulaney, Caleb R.…[et al.]. Prostate Radiotherapy in the Era of Advanced Imaging and Precision Medicine. Prostate Cancer No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1114891
American Medical Association (AMA)
Dulaney, Caleb R.& Osula, Daniel O.& Yang, Eddy S.& Rais-Bahrami, Soroush. Prostate Radiotherapy in the Era of Advanced Imaging and Precision Medicine. Prostate Cancer. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114891
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114891