Prostate Cancer: Epigenetic Alterations, Risk Factors, and Therapy
Joint Authors
Sathekge, Mike Machaba
Kgatle, Mankgopo M.
Kalla, Asgar A.
Islam, Muhammed M.
Moorad, Razia
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Prostate cancer (PCa) is the most prevalent urological cancer that affects aging men in South Africa, and mechanisms underlying prostate tumorigenesis remain elusive.
Research advancements in the field of PCa and epigenetics have allowed for the identification of specific alterations that occur beyond genetics but are still critically important in the pathogenesis of tumorigenesis.
Anomalous epigenetic changes associated with PCa include histone modifications, DNA methylation, and noncoding miRNA.
These mechanisms regulate and silence hundreds of target genes including some which are key components of cellular signalling pathways that, when perturbed, promote tumorigenesis.
Elucidation of mechanisms underlying epigenetic alterations and the manner in which these mechanisms interact in regulating gene transcription in PCa are an unmet necessity that may lead to novel chemotherapeutic approaches.
This will, therefore, aid in developing combination therapies that will target multiple epigenetic pathways, which can be used in conjunction with the current conventional PCa treatment.
American Psychological Association (APA)
Kgatle, Mankgopo M.& Kalla, Asgar A.& Islam, Muhammed M.& Sathekge, Mike Machaba& Moorad, Razia. 2016. Prostate Cancer: Epigenetic Alterations, Risk Factors, and Therapy. Prostate Cancer،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114894
Modern Language Association (MLA)
Kgatle, Mankgopo M.…[et al.]. Prostate Cancer: Epigenetic Alterations, Risk Factors, and Therapy. Prostate Cancer No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1114894
American Medical Association (AMA)
Kgatle, Mankgopo M.& Kalla, Asgar A.& Islam, Muhammed M.& Sathekge, Mike Machaba& Moorad, Razia. Prostate Cancer: Epigenetic Alterations, Risk Factors, and Therapy. Prostate Cancer. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114894
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114894