Predicting Low-Risk Prostate Cancer from Transperineal Saturation Biopsies
Joint Authors
Ting, Francis
Delprado, Warick
Brenner, Phillip
Siriwardana, Amila Rohan
van Leeuwen, Pim J.
Roobol, Monique
Nieboer, Daan
Thompson, James
Haynes, Anne-Marie
Stricker, Phillip
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
To assess the performance of five previously described clinicopathological definitions of low-risk prostate cancer (PC).
Materials and Methods.
Men who underwent radical prostatectomy (RP) for clinical stage ≤T2, PSA <10 ng/mL, Gleason score <8 PC, diagnosed by transperineal template-guided saturation biopsy were included.
The performance of five previously described criteria (i.e., criteria 1–5, criterion 1 stringent (Gleason score 6 + ≤5 mm total max core length PC + ≤3 mm max per core length PC) up to criterion 5 less stringent (Gleason score 6-7 with ≤5% Gleason grade 4) was analysed to assess ability of each to predict insignificant disease in RP specimens (defined as Gleason score ≤6 and total tumour volume <2.5 mL, or Gleason score 7 with ≤5% grade 4 and total tumour volume <0.7 mL).
Results.
994 men who underwent RP were included.
Criterion 4 (Gleason score 6) performed best with area under the curve of receiver operating characteristics 0.792.
At decision curve analysis, criterion 4 was deemed clinically the best performing transperineal saturation biopsy-based definition for low-risk PC.
Conclusions.
Gleason score 6 disease demonstrated a superior trade-off between sensitivity and specificity for clarifying low-risk PC that can guide treatment and be used as reference test in diagnostic studies.
American Psychological Association (APA)
Ting, Francis& Nieboer, Daan& Thompson, James& Delprado, Warick& Haynes, Anne-Marie& Brenner, Phillip…[et al.]. 2016. Predicting Low-Risk Prostate Cancer from Transperineal Saturation Biopsies. Prostate Cancer،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1114895
Modern Language Association (MLA)
Ting, Francis…[et al.]. Predicting Low-Risk Prostate Cancer from Transperineal Saturation Biopsies. Prostate Cancer No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1114895
American Medical Association (AMA)
Ting, Francis& Nieboer, Daan& Thompson, James& Delprado, Warick& Haynes, Anne-Marie& Brenner, Phillip…[et al.]. Predicting Low-Risk Prostate Cancer from Transperineal Saturation Biopsies. Prostate Cancer. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1114895
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114895