Can a Positive Allosteric Modulation of GABAergic Receptors Improve Motor Symptoms in Patients with Parkinson’s Disease? The Potential Role of Zolpidem in the Treatment of Parkinson’s Disease
Joint Authors
Panza, Francesco
Greco, Antonio
Daniele, Antonio
Logroscino, Giancarlo
Seripa, Davide
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-17
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
At present, patients with advanced Parkinson’s disease (PD) are unsatisfactorily controlled by currently used anti-Parkinsonian dopaminergic drugs.
Various studies suggest that therapeutic strategies based on nondopaminergic drugs might be helpful in PD.
Zolpidem, an imidazopyridine widely used as sleep inducer, shows high affinity only for G A B A A receptors containing the α-1 subunit and facilitates GABAergic neurotransmission through a positive allosteric modulation of G A B A A receptors.
Various observations, although preliminary, consistently suggest that in PD patients zolpidem may induce beneficial (and sometimes remarkable) effects on motor symptoms even after single doses and may also improve dyskinesias.
Since a high density of zolpidem binding sites is in the two main output structures of the basal ganglia which are abnormally overactive in PD (internal globus pallidus, GPi, and substantia nigra pars reticulata, SNr), it was hypothesized that in PD patients zolpidem may induce through G A B A A receptors an inhibition of GPi and SNr (and, possibly, of the subthalamic nucleus also), resulting in an increased activity of motor cortical areas (such as supplementary motor area), which may give rise to improvement of motor symptoms of PD.
Randomized clinical trials are needed in order to assess the efficacy, safety, and tolerability of zolpidem in treating motor symptoms of PD.
American Psychological Association (APA)
Daniele, Antonio& Panza, Francesco& Greco, Antonio& Logroscino, Giancarlo& Seripa, Davide. 2016. Can a Positive Allosteric Modulation of GABAergic Receptors Improve Motor Symptoms in Patients with Parkinson’s Disease? The Potential Role of Zolpidem in the Treatment of Parkinson’s Disease. Parkinson’s Disease،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1115201
Modern Language Association (MLA)
Daniele, Antonio…[et al.]. Can a Positive Allosteric Modulation of GABAergic Receptors Improve Motor Symptoms in Patients with Parkinson’s Disease? The Potential Role of Zolpidem in the Treatment of Parkinson’s Disease. Parkinson’s Disease No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1115201
American Medical Association (AMA)
Daniele, Antonio& Panza, Francesco& Greco, Antonio& Logroscino, Giancarlo& Seripa, Davide. Can a Positive Allosteric Modulation of GABAergic Receptors Improve Motor Symptoms in Patients with Parkinson’s Disease? The Potential Role of Zolpidem in the Treatment of Parkinson’s Disease. Parkinson’s Disease. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1115201
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115201