Chaperone-Mediated Autophagy and Mitochondrial Homeostasis in Parkinson’s Disease
Joint Authors
Yang, Ruixin
Gao, Guodong
Mao, Zixu
Yang, Qian
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Parkinson’s disease (PD), a complex neurodegenerative disorder, is pathologically characterized by the formation of Lewy bodies and loss of dopaminergic neurons in the substantia nigra pars compacta (SNc).
Mitochondrial dysfunction is considered to be one of the most important causative mechanisms.
In addition, dysfunction of chaperone-mediated autophagy (CMA), one of the lysosomal proteolytic pathways, has been shown to play an important role in the pathogenesis of PD.
An exciting and important development is recent finding that CMA and mitochondrial quality control may be linked.
This review summarizes the studies revealing the link between autophagy and mitochondrial function.
Discussions are focused on the connections between CMA and mitochondrial failure and on the role of MEF2D, a neuronal survival factor, in mediating the regulation of mitochondria in the context of CMA.
These new findings highlight the need to further explore the possibility of targeting the MEF2D-mitochondria-CMA network in both understanding the PD pathogenesis and developing novel therapeutic strategies.
American Psychological Association (APA)
Yang, Ruixin& Gao, Guodong& Mao, Zixu& Yang, Qian. 2016. Chaperone-Mediated Autophagy and Mitochondrial Homeostasis in Parkinson’s Disease. Parkinson’s Disease،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1115204
Modern Language Association (MLA)
Yang, Ruixin…[et al.]. Chaperone-Mediated Autophagy and Mitochondrial Homeostasis in Parkinson’s Disease. Parkinson’s Disease No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1115204
American Medical Association (AMA)
Yang, Ruixin& Gao, Guodong& Mao, Zixu& Yang, Qian. Chaperone-Mediated Autophagy and Mitochondrial Homeostasis in Parkinson’s Disease. Parkinson’s Disease. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1115204
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115204