Analysis of LRRK2, SNCA, and ITGA8 Gene Variants with Sporadic Parkinson’s Disease Susceptibility in Chinese Han Population
Joint Authors
Fang, Jie
Yi, Kehui
Guo, Mingwei
An, Xingkai
Qu, Hongli
Lin, Qing
Bi, Min
Ma, Qilin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-07
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Parkinson’s disease (PD) is an age-related neurodegenerative disease affected by multiple genetic and environmental factors.
We performed a case-control study on candidate gene to scrutinize whether genetic variants in LRRK2, SNCA, and ITGA8 genes could be associated with sporadic PD in Chinese Han population.
Methods.
Five single-nucleotide polymorphisms (SNPs) of LRRK2 (rs1491942), SNCA (rs2301134, rs2301135, and rs356221), and ITGA8 (rs7077361) were selected and genotyped among 583 unrelated PD patients and 558 healthy controls.
Results.
Rs1491942 of LRRK2 gene had a significantly higher genotype frequency ( P = 3.543 E - 09 ) and allelic G/C frequencies ( P = 2.601 E - 10 ) in PD patients than controls.
Rs2301135 of SNCA gene also showed an obvious difference in genotype frequency ( P = 4.394 E - 07 ) and allelic G/C frequencies ( P = 9.11 6 E - 13 ) between PD patients and controls.
SNPs rs2301134 and rs356221 of SNCA gene and rs7077361 of ITGA8 gene lacked the significant association with the susceptibility of PD in Chinese Han population.
Conclusions.
Our study firstly expresses that rs1491942 of LRRK2 and rs2301135 of SNCA gene are substantially associated with sporadic Parkinson’s disease in Chinese Han population.
American Psychological Association (APA)
Fang, Jie& Yi, Kehui& Guo, Mingwei& An, Xingkai& Qu, Hongli& Lin, Qing…[et al.]. 2016. Analysis of LRRK2, SNCA, and ITGA8 Gene Variants with Sporadic Parkinson’s Disease Susceptibility in Chinese Han Population. Parkinson’s Disease،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1115227
Modern Language Association (MLA)
Fang, Jie…[et al.]. Analysis of LRRK2, SNCA, and ITGA8 Gene Variants with Sporadic Parkinson’s Disease Susceptibility in Chinese Han Population. Parkinson’s Disease No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1115227
American Medical Association (AMA)
Fang, Jie& Yi, Kehui& Guo, Mingwei& An, Xingkai& Qu, Hongli& Lin, Qing…[et al.]. Analysis of LRRK2, SNCA, and ITGA8 Gene Variants with Sporadic Parkinson’s Disease Susceptibility in Chinese Han Population. Parkinson’s Disease. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1115227
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115227