A Case-Control Association Study of RANTES (-28C>G) Polymorphism as a Risk Factor for Parkinson’s Disease in Isparta, Turkey
Joint Authors
Sahin-Calapoglu, Nilufer
Demirci, Serpil
Calapoglu, Mustafa
Yasar, Baris
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Recent studies have revealed that inflammatory processes are involved in the pathogenesis of Parkinson’s disease (PD).
Multiple lines of evidence have suggested that chemokines and their receptors are involved in several neurodegenerative disorders.
We have examined whether genetic polymorphisms at the genes encoding chemokines IL-8 (-251A>T), MCP-1 (-2518A/G), and RANTES (-28C>G) and chemokine receptors CCR2 (V64I) and CCR5 (-Δ32) were associated with sporadic PD risk in Isparta, Turkey.
Method.
The pilot case-control association study included 30 PD patients and 60 control subjects, who were all genotyped with PCR-RFLP for the five polymorphisms.
Their genotype and haplotype frequencies were compared statistically.
Results.
One SNP (-28C>G) in RANTES revealed a significant association with PD (P (allele) < 0.0001, p-trend = 0.0007).
The risk allele (G) in the homozygous and dominant models (OR = 17.29 and 32.10, 95% CI = 0.86–347.24 and 1.74–591.937, resp.) suggests additional PD risk.
The haplotype TGCAN from the IL-8 (-251A>T), MCP-1 (-2518A>G), RANTES (-28C>G), CCR-2 (V64I), and CCR-5 (-Δ32) has protective effect (OR = 0.08 [CI = 0.01–0.63], p=0.019).
Conclusions.
Our data are the first indication of the role of RANTES (-28C>G) in PD risk.
American Psychological Association (APA)
Sahin-Calapoglu, Nilufer& Demirci, Serpil& Calapoglu, Mustafa& Yasar, Baris. 2016. A Case-Control Association Study of RANTES (-28C>G) Polymorphism as a Risk Factor for Parkinson’s Disease in Isparta, Turkey. Parkinson’s Disease،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1115240
Modern Language Association (MLA)
Sahin-Calapoglu, Nilufer…[et al.]. A Case-Control Association Study of RANTES (-28C>G) Polymorphism as a Risk Factor for Parkinson’s Disease in Isparta, Turkey. Parkinson’s Disease No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1115240
American Medical Association (AMA)
Sahin-Calapoglu, Nilufer& Demirci, Serpil& Calapoglu, Mustafa& Yasar, Baris. A Case-Control Association Study of RANTES (-28C>G) Polymorphism as a Risk Factor for Parkinson’s Disease in Isparta, Turkey. Parkinson’s Disease. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1115240
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115240