Altered Spontaneous Brain Activity in Cortical and Subcortical Regions in Parkinson’s Disease
Joint Authors
Li, Kuncheng
Xiang, Jie
Li, Huizhuo
Qin, Jiawei
Liang, Peipeng
Jia, Xiuqin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
The present study aimed to explore the changes of amplitude of low-frequency fluctuations (ALFF) at rest in patients with Parkinson’s disease (PD).
Methods.
Twenty-four PD patients and 22 healthy age-matched controls participated in the study.
ALFF was measured on the whole brain of all participants.
A two-sample t -test was then performed to detect the group differences with age, gender, education level, head motion, and gray matter volume as covariates.
Results.
It was showed that PD patients had significantly decreased ALFF in the left thalamus/caudate and right insula/inferior prefrontal gyrus, whereas they had increased ALFF in the right medial prefrontal cortex (BA 8/6) and dorsolateral prefrontal cortex (BA 9/10).
Conclusions.
Our results indicated that significant alterations of ALFF in the subcortical regions and prefrontal cortex have been detected in PD patients, independent of age, gender, education, head motion, and structural atrophy.
The current findings further provide insights into the biological mechanism of the disease.
American Psychological Association (APA)
Xiang, Jie& Jia, Xiuqin& Li, Huizhuo& Qin, Jiawei& Liang, Peipeng& Li, Kuncheng. 2016. Altered Spontaneous Brain Activity in Cortical and Subcortical Regions in Parkinson’s Disease. Parkinson’s Disease،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1115242
Modern Language Association (MLA)
Xiang, Jie…[et al.]. Altered Spontaneous Brain Activity in Cortical and Subcortical Regions in Parkinson’s Disease. Parkinson’s Disease No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1115242
American Medical Association (AMA)
Xiang, Jie& Jia, Xiuqin& Li, Huizhuo& Qin, Jiawei& Liang, Peipeng& Li, Kuncheng. Altered Spontaneous Brain Activity in Cortical and Subcortical Regions in Parkinson’s Disease. Parkinson’s Disease. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1115242
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115242