Mini Review: Anticholinergic Activity as a Behavioral Pathology of Lewy Body Disease and Proposal of the Concept of “Anticholinergic Spectrum Disorders”
Joint Authors
Hori, Koji
Hosoi, Misa
Konishi, Kimiko
Hachisu, Mitsugu
Kitajima, Yuka
Tomioka, Hiroi
Tani, Masayuki
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Given the relationship between anticholinergic activity (AA) and Alzheimer’s disease (AD), we rereview our hypothesis of the endogenous appearance of AA in AD.
Briefly, because acetylcholine (ACh) regulates not only cognitive function but also the inflammatory system, when ACh downregulation reaches a critical level, inflammation increases, triggering the appearance of cytokines with AA.
Moreover, based on a case report of a patient with mild AD and slightly deteriorated ACh, we also speculate that AA can appear endogenously in Lewy body disease due to the dual action of the downregulation of ACh and hyperactivity of the hypothalamic-pituitary-adrenal axis.
Based on these hypotheses, we consider AA to be a behavioral pathology of Lewy body disease.
We also propose the concept of “anticholinergic spectrum disorders,” which encompass a variety of conditions, including AD, Lewy body disease, and delirium.
Finally, we suggest the prescription of cholinesterase inhibitors to patients in this spectrum of disorders to abolish AA by upregulating ACh.
American Psychological Association (APA)
Hori, Koji& Konishi, Kimiko& Hosoi, Misa& Tomioka, Hiroi& Tani, Masayuki& Kitajima, Yuka…[et al.]. 2016. Mini Review: Anticholinergic Activity as a Behavioral Pathology of Lewy Body Disease and Proposal of the Concept of “Anticholinergic Spectrum Disorders”. Parkinson’s Disease،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1115244
Modern Language Association (MLA)
Hori, Koji…[et al.]. Mini Review: Anticholinergic Activity as a Behavioral Pathology of Lewy Body Disease and Proposal of the Concept of “Anticholinergic Spectrum Disorders”. Parkinson’s Disease No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1115244
American Medical Association (AMA)
Hori, Koji& Konishi, Kimiko& Hosoi, Misa& Tomioka, Hiroi& Tani, Masayuki& Kitajima, Yuka…[et al.]. Mini Review: Anticholinergic Activity as a Behavioral Pathology of Lewy Body Disease and Proposal of the Concept of “Anticholinergic Spectrum Disorders”. Parkinson’s Disease. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1115244
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115244