The Association between C9orf72 Repeats and Risk of Alzheimer’s Disease and Amyotrophic Lateral Sclerosis: A Meta-Analysis
Joint Authors
Zhang, Yuan
Shu, Li
Xu, Qian
Yan, Xin-xiang
Tang, Bei-sha
Sun, Qiying
Guo, Jifeng
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) in Caucasian populations.
However, the relationship between C9orf72 repeats and Alzheimer’s disease (AD) was not clear.
Additionally, there were few articles assessing C9orf72 in other ethnicities with ALS.
In this meta-analysis, we aimed to investigate the relationship between C9orf72 repeat expansions (≥30 repeats) and intermediate repeat copies (20–29 repeats) and AD or ALS.
The results suggested positive correlations between C9orf72 repeat expansions and the risk of Alzheimer’s disease (OR = 6.36, 95% CI = 3.13–12.92, and p < 0.00001 ), while intermediate repeat copies of C9orf72 gene were not associated with the risk of the disease.
C9orf72 repeat expansions were positively correlated with the risk of familial and sporadic ALS (OR = 293.25, 95% CI = 148.17–580.38, and p < 0.00001 ; OR = 35.57, 95% CI = 19.61–64.51, and p < 0.00001 ).
There was a positive correlation between the gene variations and ALS risk among Caucasians and Asians (OR = 57.56, 95% CI = 36.73–90.22, and p < 0.00001 ; OR = 6.35, 95% CI = 1.39–29.02, and p = 0.02 ).
American Psychological Association (APA)
Shu, Li& Sun, Qiying& Zhang, Yuan& Xu, Qian& Guo, Jifeng& Yan, Xin-xiang…[et al.]. 2016. The Association between C9orf72 Repeats and Risk of Alzheimer’s Disease and Amyotrophic Lateral Sclerosis: A Meta-Analysis. Parkinson’s Disease،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1115246
Modern Language Association (MLA)
Shu, Li…[et al.]. The Association between C9orf72 Repeats and Risk of Alzheimer’s Disease and Amyotrophic Lateral Sclerosis: A Meta-Analysis. Parkinson’s Disease No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1115246
American Medical Association (AMA)
Shu, Li& Sun, Qiying& Zhang, Yuan& Xu, Qian& Guo, Jifeng& Yan, Xin-xiang…[et al.]. The Association between C9orf72 Repeats and Risk of Alzheimer’s Disease and Amyotrophic Lateral Sclerosis: A Meta-Analysis. Parkinson’s Disease. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1115246
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115246