Blood Plasma of Patients with Parkinson’s Disease Increases Alpha-Synuclein Aggregation and Neurotoxicity
Joint Authors
Wang, Peng
Li, Xin
Li, Xuran
Yang, Weiwei
Yu, Shun
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-14
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
A pathological hallmark of Parkinson’s disease (PD) is formation of Lewy bodies in neurons of the brain.
This has been attributed to the spread of α-synuclein (α-syn) aggregates, which involves release of α-syn from a neuron and its reuptake by a neighboring neuron.
We found that treatment with plasma from PD patients induced more α-syn phosphorylation and oligomerization than plasma from normal subjects (NS).
Compared with NS plasma, PD plasma added to primary neuron cultures caused more cell death in the presence of extracellular α-syn.
This was supported by the observations that phosphorylated α-syn oligomers entered neurons, rapidly increased accumulated thioflavin S-positive inclusions, and induced a series of metabolic changes that included activation of polo-like kinase 2, inhibition of glucocerebrosidase and protein phosphatase 2A, and reduction of ceramide levels, all of which have been shown to promote α-syn phosphorylation and aggregation.
We also analyzed neurotoxicity of α-syn oligomers relative to plasma from different patients.
Neurotoxicity was not related to age or gender of the patients.
However, neurotoxicity was positively correlated with H&Y staging score.
The modification in the plasma may promote spreading of α-syn aggregates via an alternative pathway and accelerate progression of PD.
American Psychological Association (APA)
Wang, Peng& Li, Xin& Li, Xuran& Yang, Weiwei& Yu, Shun. 2016. Blood Plasma of Patients with Parkinson’s Disease Increases Alpha-Synuclein Aggregation and Neurotoxicity. Parkinson’s Disease،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1115265
Modern Language Association (MLA)
Wang, Peng…[et al.]. Blood Plasma of Patients with Parkinson’s Disease Increases Alpha-Synuclein Aggregation and Neurotoxicity. Parkinson’s Disease No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1115265
American Medical Association (AMA)
Wang, Peng& Li, Xin& Li, Xuran& Yang, Weiwei& Yu, Shun. Blood Plasma of Patients with Parkinson’s Disease Increases Alpha-Synuclein Aggregation and Neurotoxicity. Parkinson’s Disease. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1115265
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115265