Neuroprotective Effects of Salidroside in the MPTP Mouse Model of Parkinson’s Disease: Involvement of the PI3KAktGSK3β Pathway
Joint Authors
Zhang, Wei
He, Hong
Song, Hujie
Zhao, Junjie
Li, Tao
Wu, Leitao
Zhang, Xiaojun
Chen, Jianzong
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The degenerative loss through apoptosis of dopaminergic neurons in the substantia nigra pars compacta plays a primary role in the progression of Parkinson’s disease (PD).
Our in vitro experiments suggested that salidroside (Sal) could protect against 1-methyl-4-phenylpyridine-induced cell apoptosis in part by regulating the PI3K/Akt/GSK3β pathway.
The current study aims to increase our understanding of the protective mechanisms of Sal in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropypridine- (MPTP-) induced PD mouse model.
We found that pretreatment with Sal could protect against MPTP-induced increase of the time of turning downwards and climbing down to the floor.
Sal also prevented MPTP-induced decrease of locomotion frequency and the increase of the immobile time.
Sal provided a protection of in MPTP-induced loss of tyrosine hydroxylase-positive neurons in SNpc and the level of DA, DOPAC, and HVA in the striatum.
Furthermore, Sal could increase the phosphorylation level of Akt and GSK3β, upregulate the ratio of Bcl-2/Bax, and inhibit the activation of caspase-3, caspase-6, and caspase-9.
These results show that Sal prevents the loss of dopaminergic neurons and the PI3K/Akt/GSK3β pathway signaling pathway may have mediated the protection of Sal against MPTP, suggesting that Sal may be a potential candidate in neuroprotective treatment for PD.
American Psychological Association (APA)
Zhang, Wei& He, Hong& Song, Hujie& Zhao, Junjie& Li, Tao& Wu, Leitao…[et al.]. 2016. Neuroprotective Effects of Salidroside in the MPTP Mouse Model of Parkinson’s Disease: Involvement of the PI3KAktGSK3β Pathway. Parkinson’s Disease،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1115280
Modern Language Association (MLA)
Zhang, Wei…[et al.]. Neuroprotective Effects of Salidroside in the MPTP Mouse Model of Parkinson’s Disease: Involvement of the PI3KAktGSK3β Pathway. Parkinson’s Disease No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1115280
American Medical Association (AMA)
Zhang, Wei& He, Hong& Song, Hujie& Zhao, Junjie& Li, Tao& Wu, Leitao…[et al.]. Neuroprotective Effects of Salidroside in the MPTP Mouse Model of Parkinson’s Disease: Involvement of the PI3KAktGSK3β Pathway. Parkinson’s Disease. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1115280
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115280