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Study of Exhaled Nitric Oxide in Subjects with Suspected Obstructive Sleep Apnea: A Pilot Study in Vietnam
Joint Authors
Duong-Quy, Sy
Hua-Huy, Thong
Tran-Mai-Thi, Huyen-Tran
Le-Dong, Nhat-Nam
Dinh-Xuan, Anh-Tuan
Craig, Timothy J.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Objective.
The concentration of exhaled nitric oxide (eNO), reflecting the activity of inducible NO synthase in airway epithelium, has been found to increase in patients with obstructive sleep apnea (OSA).
This study aimed to measure eNO concentration in patients with suspected OSA and to correlate different eNO parameters with clinical and sleep apnea characteristics.
Methods.
In this cross-sectional study, all patients underwent in-lab overnight polysomnography (PSG) and eNO measurement using a method of multiple flow rates before and after PSG (pre- and post-PSG).
Results.
According to the result of PSG, 82 persons were divided into two groups: control subjects (n=30; 54±14 years) and patients with OSA defined as apnea-hypopnea index (AHI) ≥ 5/hour (n=52; 53±12 years).
Body mass index (BMI) and neck and abdomen circumferences of OSA patients were significantly higher than those from control subjects.
In OSA group, post-PSG alveolar NO concentration (CANO) (5.3±1.9 ppb) was significantly higher than pre-PSG CANO (4.0±1.7 ppb; P<0.001).
Significant correlations have been found between CANO and AHI (P<0.001) and between CANO and nadir SpO2 (P<0.05).
The daytime CANO value of more than 4.1 ppb can be used to screen symptomatic subjects for the presence of OSA with a high specificity of 93.3%.
Conclusion.
Our findings indicate CANO as a surrogate marker for OSA in persons with suggestive symptoms.
American Psychological Association (APA)
Duong-Quy, Sy& Hua-Huy, Thong & Tran-Mai-Thi, Huyen-Tran& Le-Dong, Nhat-Nam& Craig, Timothy J.& Dinh-Xuan, Anh-Tuan. 2016. Study of Exhaled Nitric Oxide in Subjects with Suspected Obstructive Sleep Apnea: A Pilot Study in Vietnam. Pulmonary Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1115292
Modern Language Association (MLA)
Duong-Quy, Sy…[et al.]. Study of Exhaled Nitric Oxide in Subjects with Suspected Obstructive Sleep Apnea: A Pilot Study in Vietnam. Pulmonary Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1115292
American Medical Association (AMA)
Duong-Quy, Sy& Hua-Huy, Thong & Tran-Mai-Thi, Huyen-Tran& Le-Dong, Nhat-Nam& Craig, Timothy J.& Dinh-Xuan, Anh-Tuan. Study of Exhaled Nitric Oxide in Subjects with Suspected Obstructive Sleep Apnea: A Pilot Study in Vietnam. Pulmonary Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1115292
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115292