Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis
Joint Authors
Tinahones, Francisco J.
Bandera Merchan, Borja
Macías-González, Manuel
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-08
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The PPAR nuclear receptor family has acquired great relevance in the last decade, which is formed by three different isoforms (PPARα, PPAR β /δ, and PPAR ϒ).
Those nuclear receptors are members of the steroid receptor superfamily which take part in essential metabolic and life-sustaining actions.
Specifically, PPARG has been implicated in the regulation of processes concerning metabolism, inflammation, atherosclerosis, cell differentiation, and proliferation.
Thus, a considerable amount of literature has emerged in the last ten years linking PPARG signalling with metabolic conditions such as obesity and diabetes, cardiovascular disease, and, more recently, cancer.
This review paper, at crossroads of basic sciences, preclinical, and clinical data, intends to analyse the last research concerning PPARG signalling in obesity and cancer.
Afterwards, possible links between four interrelated actors will be established: PPARG, the vitamin D/VDR system, obesity, and cancer, opening up the door to further investigation and new hypothesis in this fascinating area of research.
American Psychological Association (APA)
Bandera Merchan, Borja& Tinahones, Francisco J.& Macías-González, Manuel. 2016. Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis. PPAR Research،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1115309
Modern Language Association (MLA)
Bandera Merchan, Borja…[et al.]. Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis. PPAR Research No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1115309
American Medical Association (AMA)
Bandera Merchan, Borja& Tinahones, Francisco J.& Macías-González, Manuel. Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis. PPAR Research. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1115309
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115309