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PPAR Ligands Function as Suppressors That Target Biological Actions of HMGB1
Joint Authors
Lou, Jian-Lin
Ying, Shibo
Xiao, Xiang
Chen, Tianhui
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
High mobility group box 1 (HMGB1), which has become one of the most intriguing molecules in inflammatory disorders and cancers and with which ligand-activated peroxisome proliferator-activated receptors (PPARs) are highly associated, is considered as a therapeutic target.
Of particular interest is the fact that certain PPAR ligands have demonstrated their potent anti-inflammatory activities and potential anticancer effects.
In this review article we summarize recent experimental evidence that PPAR ligands function as suppressors that target biological actions of HMGB1, including intracellular expression, receptor signaling cascades, and extracellular secretion of HMGB1 in cell lines and/or animal models.
We also propose the possible mechanisms underlying PPAR involvement in inflammatory disorders and discuss the future therapeutic value of PPAR ligands targeting HMGB1 molecule for cancer prevention and treatment.
American Psychological Association (APA)
Ying, Shibo& Xiao, Xiang& Chen, Tianhui& Lou, Jian-Lin. 2016. PPAR Ligands Function as Suppressors That Target Biological Actions of HMGB1. PPAR Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1115310
Modern Language Association (MLA)
Ying, Shibo…[et al.]. PPAR Ligands Function as Suppressors That Target Biological Actions of HMGB1. PPAR Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1115310
American Medical Association (AMA)
Ying, Shibo& Xiao, Xiang& Chen, Tianhui& Lou, Jian-Lin. PPAR Ligands Function as Suppressors That Target Biological Actions of HMGB1. PPAR Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1115310
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115310