Peroxisome Proliferator-Activated Receptor γ Induces the Expression of Tissue Factor Pathway Inhibitor-1 (TFPI-1) in Human Macrophages
Joint Authors
Marx, Nikolaus
Chinetti-Gbaguidi, G.
Copin, C.
Derudas, B.
Eechkoute, J.
Staels, Bart
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Tissue factor (TF) is the initiator of the blood coagulation cascade after interaction with the activated factor VII (FVIIa).
Moreover, the TF/FVIIa complex also activates intracellular signalling pathways leading to the production of inflammatory cytokines.
The TF/FVIIa complex is inhibited by the tissue factor pathway inhibitor-1 (TFPI-1).
Peroxisome proliferator-activated receptor gamma (PPARγ) is a transcription factor that, together with PPARα and PPARβ/δ, controls macrophage functions.
However, whether PPARγ activation modulates the expression of TFP1-1 in human macrophages is not known.
Here we report that PPARγ activation increases the expression of TFPI-1 in human macrophages in vitro as well as in vivo in circulating peripheral blood mononuclear cells.
The induction of TFPI-1 expression by PPARγ ligands, an effect shared by the activation of PPARα and PPARβ/δ, occurs also in proinflammatory M1 and in anti-inflammatory M2 polarized macrophages.
As a functional consequence, treatment with PPARγ ligands significantly reduces the inflammatory response induced by FVIIa, as measured by variations in the IL-8, MMP-2, and MCP-1 expression.
These data identify a novel role for PPARγ in the control of TF the pathway.
American Psychological Association (APA)
Chinetti-Gbaguidi, G.& Copin, C.& Derudas, B.& Marx, Nikolaus& Eechkoute, J.& Staels, Bart. 2016. Peroxisome Proliferator-Activated Receptor γ Induces the Expression of Tissue Factor Pathway Inhibitor-1 (TFPI-1) in Human Macrophages. PPAR Research،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1115311
Modern Language Association (MLA)
Chinetti-Gbaguidi, G.…[et al.]. Peroxisome Proliferator-Activated Receptor γ Induces the Expression of Tissue Factor Pathway Inhibitor-1 (TFPI-1) in Human Macrophages. PPAR Research No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1115311
American Medical Association (AMA)
Chinetti-Gbaguidi, G.& Copin, C.& Derudas, B.& Marx, Nikolaus& Eechkoute, J.& Staels, Bart. Peroxisome Proliferator-Activated Receptor γ Induces the Expression of Tissue Factor Pathway Inhibitor-1 (TFPI-1) in Human Macrophages. PPAR Research. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1115311
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115311