Testosterone Replacement Modulates Cardiac Metabolic Remodeling after Myocardial Infarction by Upregulating PPARα
Joint Authors
Yang, Jing
Wang, Fengyue
Sun, Weiju
Dong, Yanli
Li, Mingyu
Fu, Lu
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Despite the importance of testosterone as a metabolic hormone, its effects on myocardial metabolism in the ischemic heart remain unclear.
Myocardial ischemia leads to metabolic remodeling, ultimately resulting in ATP deficiency and cardiac dysfunction.
In the present study, the effects of testosterone replacement on the ischemic heart were assessed in a castrated rat myocardial infarction model established by ligating the left anterior descending coronary artery 2 weeks after castration.
The results of real-time PCR and Western blot analyses showed that peroxisome proliferator-activated receptor α (PPARα) decreased in the ischemic myocardium of castrated rats, compared with the sham-castration group, and the mRNA expression of genes involved in fatty acid metabolism (the fatty acid translocase CD36, carnitine palmitoyltransferase I, and medium-chain acyl-CoA dehydrogenase) and glucose transporter-4 also decreased.
A decline in ATP levels in the castrated rats was accompanied by increased cardiomyocyte apoptosis and fibrosis and impaired cardiac function, compared with the sham-castration group, and these detrimental effects were reversed by testosterone replacement.
Taken together, our findings suggest that testosterone can modulate myocardial metabolic remodeling by upregulating PPARα after myocardial infarction, exerting a protective effect on cardiac function.
American Psychological Association (APA)
Yang, Jing& Wang, Fengyue& Sun, Weiju& Dong, Yanli& Li, Mingyu& Fu, Lu. 2016. Testosterone Replacement Modulates Cardiac Metabolic Remodeling after Myocardial Infarction by Upregulating PPARα. PPAR Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1115316
Modern Language Association (MLA)
Yang, Jing…[et al.]. Testosterone Replacement Modulates Cardiac Metabolic Remodeling after Myocardial Infarction by Upregulating PPARα. PPAR Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1115316
American Medical Association (AMA)
Yang, Jing& Wang, Fengyue& Sun, Weiju& Dong, Yanli& Li, Mingyu& Fu, Lu. Testosterone Replacement Modulates Cardiac Metabolic Remodeling after Myocardial Infarction by Upregulating PPARα. PPAR Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1115316
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115316