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Nutrigenomic Functions of PPARs in Obesogenic Environments
Joint Authors
Chung, Soonkyu
Kim, Young Jun
Yang, Soo Jin
Lee, Yunkyoung
Lee, Myoungsook
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-30
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that mediate the effects of several nutrients or drugs through transcriptional regulation of their target genes in obesogenic environments.
This review consists of three parts.
First, we summarize current knowledge regarding the role of PPARs in governing the development of white and brown/beige adipocytes from uncommitted progenitor cells.
Next, we discuss the interactions of dietary bioactive molecules, such as fatty acids and phytochemicals, with PPARs for the modulation of PPAR-dependent transcriptional activities and metabolic consequences.
Lastly, the effects of PPAR polymorphism on obesity and metabolic outcomes are discussed.
In this review, we aim to highlight the critical role of PPARs in the modulation of adiposity and subsequent metabolic adaptation in response to dietary challenges and genetic modifications.
Understanding the changes in obesogenic environments as a consequence of PPARs/nutrient interactions may help expand the field of individualized nutrition to prevent obesity and obesity-associated metabolic comorbidities.
American Psychological Association (APA)
Chung, Soonkyu& Kim, Young Jun& Yang, Soo Jin& Lee, Yunkyoung& Lee, Myoungsook. 2016. Nutrigenomic Functions of PPARs in Obesogenic Environments. PPAR Research،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1115322
Modern Language Association (MLA)
Chung, Soonkyu…[et al.]. Nutrigenomic Functions of PPARs in Obesogenic Environments. PPAR Research No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1115322
American Medical Association (AMA)
Chung, Soonkyu& Kim, Young Jun& Yang, Soo Jin& Lee, Yunkyoung& Lee, Myoungsook. Nutrigenomic Functions of PPARs in Obesogenic Environments. PPAR Research. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1115322
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115322